GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function (Q28254935)

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English	GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function	scientific article

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scholarly article

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GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function (English)

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G protein-coupled receptor

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object named as

William I Weis

9

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Raymond C Stevens

object named as

Raymond C Stevens

10

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11

object named as

Brian K Kobilka

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Tong Sun Kobilka

6

object named as

Tong Sun Kobilka

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Søren G. F. Rasmussen

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ORCID Public Data File 2021

2

object named as

Vadim Cherezov

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Michael A Hanson

3

object named as

Michael A Hanson

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author name string

Daniel M Rosenbaum

1

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Søren G F Rasmussen

4

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Foon Sun Thian

5

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Hee-Jung Choi

7

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Xiao-Jie Yao

8

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language of work or name

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publication date

23 November 2007

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318

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1266-73

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5854

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

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https://api.crossref.org/works/10.1126/SCIENCE.1150609

21 April 2017

Protein flexibility and adaptability seen in 25 crystal forms of T4 lysozyme

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https://api.crossref.org/works/10.1126/SCIENCE.1150609

21 April 2017

Structure of bacteriophage T4 lysozyme refined at 1.7 A resolution

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150609

21 April 2017

GPCRDB information system for G protein-coupled receptors

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https://api.crossref.org/works/10.1126/SCIENCE.1150609

21 April 2017

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150609

21 April 2017

Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150609

21 April 2017

The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

The role of the seventh transmembrane region in high affinity binding of a beta 2-selective agonist TA-2005

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Role of group-conserved residues in the helical core of beta2-adrenergic receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Conformational complexity of G-protein-coupled receptors

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Identification of residues required for ligand binding to the beta-adrenergic receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Identification of a conserved switch residue responsible for selective constitutive activation of the beta2-adrenergic receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Stabilization of phage T4 lysozyme by engineered disulfide bonds

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Beta(1)-selective agonist (-)-1-(3,4-dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(-)-RO363] differentially interacts with key amino acids responsible for beta(1)-selective binding in resting and active states

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Crystal structures of fusion proteins with large-affinity tags

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

A dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalization

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.1150609

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