CD4-CD8 lineage commitment: an inside view (Q36202203)

12 August 2017

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title

CD4-CD8 lineage commitment: an inside view (English)

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12 August 2017

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1

Dietmar J Kappes

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12 August 2017

Xiao He

2

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12 August 2017

Xi He

series ordinal

3

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12 August 2017

language of work or name

English

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publication date

1 August 2005

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12 August 2017

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12 August 2017

6

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12 August 2017

8

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12 August 2017

761-766

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https://scigraph.springernature.com/pub.10.1038/ni1230

12 August 2017

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cites work

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.

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Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.

21 January 2018

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Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes

21 January 2018

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Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

21 January 2018

1 reference

Another view of the selective model of thymocyte selection.

21 January 2018

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A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice.

21 January 2018

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Stochastic component to development of class I major histocompatibility complex-specific T cells

21 January 2018

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Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.

21 January 2018

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T-cell development and the CD4-CD8 lineage decision

21 January 2018

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MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

21 January 2018

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Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways

21 January 2018

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Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

21 January 2018

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Lck activity controls CD4/CD8 T cell lineage commitment.

21 January 2018

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Csk controls antigen receptor-mediated development and selection of T-lineage cells.

21 January 2018

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The influence of the MAPK pathway on T cell lineage commitment

21 January 2018

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The Ras/MAPK cascade and the control of positive selection

21 January 2018

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The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.

21 January 2018

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Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.

21 January 2018

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Visualization of CD4/CD8 T cell commitment

21 January 2018

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The regulation of CD4 and CD8 coreceptor gene expression during T cell development

21 January 2018

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T cell development: bottoms-up

21 January 2018

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A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

21 January 2018

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Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation.

21 January 2018

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An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells.

21 January 2018

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Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells.

21 January 2018

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Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.

21 January 2018

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Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression.

21 January 2018

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Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

21 January 2018

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Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

21 January 2018

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Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes

21 January 2018

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Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4-/CD8+ thymocytes

21 January 2018

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Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes

21 January 2018

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Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

21 January 2018

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Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter

21 January 2018

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Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

21 January 2018

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A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

21 January 2018

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The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells

21 January 2018

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Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

21 January 2018

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Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development

21 January 2018

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Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division

21 January 2018

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Centromeric repositioning of coreceptor loci predicts their stable silencing and the CD4/CD8 lineage choice.

21 January 2018

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Dynamic repositioning of CD4 and CD8 genes during T cell development.

21 January 2018

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Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding

21 January 2018

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The CD8alpha gene locus is regulated by the Ikaros family of proteins.

21 January 2018

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Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin

21 January 2018

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Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

21 January 2018

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The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.

21 January 2018

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HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells

21 January 2018

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Regulation of lineage commitment distinct from positive selection.

21 January 2018

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Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection

21 January 2018

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GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation

21 January 2018

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Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.

21 January 2018

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c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin

21 January 2018

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Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression

21 January 2018

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Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice.

21 January 2018

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Critical roles for transcription factor GATA-3 in thymocyte development

21 January 2018

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The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression

21 January 2018

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An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

21 January 2018

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TOX: an HMG box protein implicated in the regulation of thymocyte selection

21 January 2018

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TOX provides a link between calcineurin activation and CD8 lineage commitment

21 January 2018

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Notch signaling in lymphocyte development and function

21 January 2018

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Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

21 January 2018

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Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.

21 January 2018

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Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

21 January 2018

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Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

21 January 2018

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7 January 2021

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

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7 January 2021

A transcriptional silencer controls the developmental expression of the CD4 gene.

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7 January 2021

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

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7 January 2021

A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice

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7 January 2021

Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage

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7 January 2021

Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage

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7 January 2021

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

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7 January 2021

Programming for cytotoxic effector function occurs concomitantly with CD4 extinction during CD8(+) T cell differentiation in the thymus

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7 January 2021

A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development

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7 January 2021

Identifiers

DOI

10.1038/NI1230

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Dimensions Publication ID

12 August 2017

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