TOX provides a link between calcineurin activation and CD8 lineage commitment (Q24647569)

GOA release 2020-03-11

1 reference

Jeffery D Molkentin

7

0 references

author name string

Parinaz Aliahmad

1

0 references

Emmett O'Flaherty

2

0 references

Peggy Han

3

0 references

Olivia D Goularte

4

0 references

Beverley Wilkinson

5

0 references

Masanobu Satake

6

0 references

Jonathan Kaye

Journal of Experimental Medicine

8

0 references

language of work or name

English

0 references

publication date

19 April 2004

0 references

published in

0 references

volume

199

0 references

page(s)

1089-99

0 references

issue

8

0 references

cites work

TOX defines a conserved subfamily of HMG-box proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

DNA recognition by the RUNX1 transcription factor is mediated by an allosteric transition in the RUNT domain and by DNA bending

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Thymocyte development in early growth response gene 1-deficient mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

NFAT signaling: choreographing the social lives of cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

HMG1 and 2, and related 'architectural' DNA-binding proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Defective T cell development and function in calcineurin A beta -deficient mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

RAG-1-deficient mice have no mature B and T lymphocytes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Priming the nucleosome: a role for HMGB proteins?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Positive and negative selection of T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

TOX: an HMG box protein implicated in the regulation of thymocyte selection

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

T cell receptor-mediated signs and signals governing T cell development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Induction of the early growth response (Egr) family of transcription factors during thymic selection

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Mice lacking major histocompatibility complex class I and class II molecules

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Lck activity controls CD4/CD8 T cell lineage commitment.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

The influence of the MAPK pathway on T cell lineage commitment

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

TCR engagement of CD4+CD8+ thymocytes in vitro induces early aspects of positive selection, but not apoptosis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Positive and negative selection of an antigen receptor on T cells in transgenic mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Abnormal differentiation of thymocytes in mice treated with cyclosporin A.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

The majority of CD4+8- thymocytes are functionally immature

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

The CD8alpha gene locus is regulated by the Ikaros family of proteins.

30 May 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

The quantity of TCR signal determines positive selection and lineage commitment of T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: a threshold model

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Duration of calcineurin and Erk signals regulates CD4/CD8 lineage commitment of thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

CD69 expression during selection and maturation of CD4+8+ thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Hierarchical interactions control CD4 gene expression during thymocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Demethylated CD8 gene in CD4+ T cells suggests that CD4+ cells develop from CD8+ precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211890

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

28 November 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Effects of cyclosporine A on T cell development and clonal deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Calcineurin Aalpha plays an exclusive role in TCR signaling in mature but not in immature T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Effects of a constitutively active form of calcineurin on T cell activation and thymic selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Involvement of p21ras activation in T cell CD69 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040051

Slow accumulation of active mitogen-activated protein kinase during thymocyte differentiation regulates the temporal pattern of transcription factor gene expression

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15078895