Natural product discovery: past, present, and future (Q35887454)

10 August 2017

Natural product discovery: past, present, and future (English)

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10 August 2017

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Leonard Katz

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PubMed ID

26739136

10 August 2017

Richard H Baltz

series ordinal

2

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10 August 2017

6 January 2016

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Journal of Industrial Microbiology & Biotechnology

10 August 2017

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10 August 2017

43

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10 August 2017

2-3

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10 August 2017

155-176

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Construction of Biologically Functional Bacterial Plasmids In Vitro

10 August 2017

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12 December 2020

Production of novel lipopeptide antibiotics related to A54145 by Streptomyces fradiae mutants blocked in biosynthesis of modified amino acids and assignment of lptJ, lptK and lptL gene functions.

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12 December 2020

Efficient plasmid transformation of Streptomyces ambofaciens and Streptomyces fradiae protoplasts

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12 December 2020

A hybrid modular polyketide synthase obtained by domain swapping

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12 December 2020

Microbial natural products: molecular blueprints for antitumor drugs.

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12 December 2020

A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermecti

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12 December 2020

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

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12 December 2020

Development of a genetic system for combinatorial biosynthesis of lipopeptides in Streptomyces fradiae and heterologous expression of the A54145 biosynthesis gene cluster

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12 December 2020

Culture-independent discovery of natural products from soil metagenomes

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12 December 2020

The spinosyn family of insecticides: realizing the potential of natural products research

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12 December 2020

Combinatorial biosynthesis of cyclic lipopeptide antibiotics: a model for synthetic biology to accelerate the evolution of secondary metabolite biosynthetic pathways

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12 December 2020

Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase.

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12 December 2020

Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases

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12 December 2020

Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365.

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12 December 2020

Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives.

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12 December 2020

Genomic basis for natural product biosynthetic diversity in the actinomycetes

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12 December 2020

The controversial early history of cyclosporin.

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12 December 2020

Production of a hybrid macrolide antibiotic in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans

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12 December 2020

Antibiotic from Micromonospora

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12 December 2020

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

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12 December 2020

Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus

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12 December 2020

Genome mining of Streptomyces ambofaciens.

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12 December 2020

Triggers and cues that activate antibiotic production by actinomycetes

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12 December 2020

Draft Genome Sequence of Streptomyces rapamycinicus Strain NRRL 5491, the Producer of the Immunosuppressant Rapamycin

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12 December 2020

The evolving role of natural products in drug discovery

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12 December 2020

Bleomycin and other antitumor antibiotics of high molecular weight

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12 December 2020

Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery

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12 December 2020

Mutational biosynthesis--a tool for the generation of structural diversity in the biosynthesis of antibiotics

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12 December 2020

Mining the metabiome: identifying novel natural products from microbial communities

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12 December 2020

Biosynthesis of peptide antibiotics

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12 December 2020

Phosphonomycin. I. Discovery and in vitro biological characterization

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12 December 2020

Structural rearrangements of a polyketide synthase module during its catalytic cycle

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12 December 2020

Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)

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12 December 2020

Transformation of plasmid DNA into Streptomyces at high frequency

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12 December 2020

Drugs for bad bugs: confronting the challenges of antibacterial discovery

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12 December 2020

Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways

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12 December 2020

Neural network-based QSAR and insecticide discovery: spinetoram.

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12 December 2020

An overview of FDA-approved new molecular entities: 1827-2013.

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12 December 2020

Preparation of four new antibiotics from a mutant of Streptomyces fradiae

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12 December 2020

Natural products as sources of new drugs over the 30 years from 1981 to 2010

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12 December 2020

Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability

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12 December 2020

Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors

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12 December 2020

DAUNOMYCIN: A NEW ANTIBIOTIC WITH ANTITUMOR ACTIVITY

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12 December 2020

Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350

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12 December 2020

Inhibition of the immune response by rapamycin, a new antifungal antibiotic

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12 December 2020

Harnessing natural product assembly lines: structure, promiscuity, and engineering

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12 December 2020

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

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12 December 2020

Genetics and biochemistry on tylosin production: a model for genetic engineering in antibiotic-producing Streptomyces

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12 December 2020

New aminocoumarin antibiotics as gyrase inhibitors.

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12 December 2020

Activating secondary metabolism with stress and chemicals

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12 December 2020

Phenotypic screening in cancer drug discovery - past, present and future

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12 December 2020

.beta.-Lactam antibiotics from Streptomyces

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12 December 2020

A modified method of mixed lymphocyte reaction: establishment of the assay system and its application to extracts of fungal cultures

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12 December 2020

Streptomyces metabolites in divergent microbial interactions

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12 December 2020

Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement

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12 December 2020

The influence of natural products upon drug discovery

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12 December 2020

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

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12 December 2020

Thoughts and facts about antibiotics: where we are now and where we are heading

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12 December 2020

Comparison of the effects of FK-506, cyclosporin A and rapamycin on IL-2 production

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12 December 2020

Natural product derived insecticides: discovery and development of spinetoram

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12 December 2020

Assembly line polyketide synthases: mechanistic insights and unsolved problems

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12 December 2020

Current trends in microbial diagnostics based on mass spectrometry.

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12 December 2020

Importance of microbial natural products and the need to revitalize their discovery

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12 December 2020

Using Genomics for Natural Product Structure Elucidation

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12 December 2020

antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters

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12 December 2020

A historical perspective on the discovery of statins

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12 December 2020

Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production

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12 December 2020

Metabolic profiling as a tool for prioritizing antimicrobial compounds

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12 December 2020

Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

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12 December 2020

Computational approaches to natural product discovery

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12 December 2020

Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis

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12 December 2020

Natural products as probes in pharmaceutical research

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12 December 2020

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

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12 December 2020

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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12 December 2020

Control of tylosin biosynthesis in Streptomyces fradiae.

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12 December 2020

Molecular insights on the biosynthesis of antitumour compounds by actinomycetes

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12 December 2020

Monacolin K, a new hypocholesterolemic agent produced by a Monascus species.

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12 December 2020

A cryptic antibiotic triggered by monensin

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12 December 2020

Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis.

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12 December 2020

Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements

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12 December 2020

Quinolones: from antibiotics to autoinducers

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12 December 2020

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

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12 December 2020

The NCI60 human tumour cell line anticancer drug screen

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12 December 2020

Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts

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12 December 2020

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

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12 December 2020

Streptomyces temperate bacteriophage integration systems for stable genetic engineering of actinomycetes (and other organisms).

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12 December 2020

Antibiotic resistance-mediated isolation of scaffold-specific natural product producers

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12 December 2020

Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa

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12 December 2020

Generation of new epothilones by genetic engineering of a polyketide synthase in Myxococcus xanthus.

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12 December 2020

Structure of a modular polyketide synthase

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12 December 2020

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

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12 December 2020

Molecular engineering approaches to peptide, polyketide and other antibiotics

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12 December 2020

Next-generation antimicrobials: from chemical biology to first-in-class drugs

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12 December 2020

The history of cyclosporin A (Sandimmune) revisited: another point of view

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12 December 2020

Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery

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12 December 2020

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

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12 December 2020

Global biogeographic sampling of bacterial secondary metabolism

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12 December 2020

Studies on antitumor activity of mitomycin

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12 December 2020

Informatic search strategies to discover analogues and variants of natural product archetypes.

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12 December 2020

Reinvigorating natural product combinatorial biosynthesis with synthetic biology

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12 December 2020

Production of a novel polyketide through the construction of a hybrid polyketide synthase.

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12 December 2020

Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis

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12 December 2020

Natural product and natural product derived drugs in clinical trials.

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12 December 2020

Studies on the antitumor activity, mechanism of action, and cell cycle effects of camptothecin

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12 December 2020

Renaissance in antibacterial discovery from actinomycetes

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12 December 2020

Using NMR to identify and characterize natural products

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12 December 2020

Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology

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12 December 2020

Marcel Faber Roundtable: is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?

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12 December 2020

Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives

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12 December 2020

The antibiotic resistome: the nexus of chemical and genetic diversity

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12 December 2020

The structural biology of biosynthetic megaenzymes

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12 December 2020

Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes

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12 December 2020

Immobilization of Streptomyces thermotolerans 11432 on polyurethane foam to improve production of acetylisovaleryltylosin.

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12 December 2020

Streptomycetes in micro-cultures: growth, production of secondary metabolites, and storage and retrieval in the 96-well format

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12 December 2020

Combinatorial biosynthesis of novel antibiotics related to daptomycin

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12 December 2020

Properties of Streptomyces fradiae Mutants Blocked in Biosynthesis of the Macrolide Antibiotic Tylosin

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12 December 2020

How were new medicines discovered?

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12 December 2020

Biosynthetic genes for aminoglycoside antibiotics

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12 December 2020

Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology

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12 December 2020

Target deconvolution strategies in drug discovery

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12 December 2020

Strain improvement in actinomycetes in the postgenomic era.

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12 December 2020

Phosphonomycin, a New Antibiotic Produced by Strains of Streptomyces

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12 December 2020

Leveraging ecological theory to guide natural product discovery

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12 December 2020

Daptomycin: from the mountain to the clinic, with essential help from Francis Tally, MD.

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12 December 2020

Genetically engineered lipopeptide antibiotics related to A54145 and daptomycin with improved properties

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12 December 2020

MbtH homology codes to identify gifted microbes for genome mining.

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12 December 2020

Monacolin K, a new hypocholesterolemic agent produced by a Monascus species.

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.32.852

Identifiers

DOI

10.1007/S10295-015-1723-5

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10 August 2017

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PubMed ID

26739136