Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement (Q38101241)

28 August 2017

Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement (English)

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Streptomyces clavuligerus

28 August 2017

object named as

Streptomyces clavuligerus

2 references

1 reference

Ashish Paradkar

1

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28 August 2017

24 April 2013

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PubMed ID

23612724

full work available at URL

28 August 2017

https://www.nature.com/articles/ja201326.pdf

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1038/ja.2013.26?email=unpaywall_01@example.com

published in

The Journal of Antibiotics

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28 August 2017

66

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28 August 2017

7

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28 August 2017

411-420

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https://api.unpaywall.org/v2/10.1038/ja.2013.26?email=unpaywall_01@example.com

28 August 2017

1 reference

19 March 2024

access restriction status

open access

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inferred from online access status

exact match

https://scigraph.springernature.com/pub.10.1038/ja.2013.26

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Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene

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Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.

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ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid

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7 January 2021

.beta.-Lactam antibiotics from Streptomyces

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7 January 2021

Studies on the biosynthesis of clavulanic acid. III. Incorporation of DL-[3,4-13C2]glutamic acid

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7 January 2021

Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit.

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7 January 2021

The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces

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7 January 2021

Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus

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7 January 2021

Three unlinked gene clusters are involved in clavam metabolite biosynthesis in Streptomyces clavuligerus

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7 January 2021

Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analogue

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7 January 2021

Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein.

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7 January 2021

Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production

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7 January 2021

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7 January 2021

Identifiers

DOI

10.1038/JA.2013.26

1 reference

PubMed ID

23612724

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23612724