Reinvigorating natural product combinatorial biosynthesis with synthetic biology (Q36590659)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26284672%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Reinvigorating natural product combinatorial biosynthesis with synthetic biology (English)

1 reference

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22 February 2020

1 reference

1 reference

corrigendum / erratum

Erratum: Reinvigorating natural product combinatorial biosynthesis with synthetic biology

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author

Bradley S. Moore

series ordinal

2

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22 February 2020

author name string

Eunji Kim

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26284672%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Yeo Joon Yoon

series ordinal

3

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22 February 2020

publication date

1 September 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26284672%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

published in

Nature Chemical Biology

1 reference

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22 February 2020

volume

11

1 reference

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22 February 2020

issue

9

1 reference

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22 February 2020

page(s)

649-659

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https://scigraph.springernature.com/pub.10.1038/nchembio.1893

22 February 2020

exact match

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Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.

9 September 2017

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9 September 2017

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Cyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product Biosynthesis

9 September 2017

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9 September 2017

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9 September 2017

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Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes

9 September 2017

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Recent advances in the heterologous expression of microbial natural product biosynthetic pathways

9 September 2017

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Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2).

9 September 2017

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Engineering the acyltransferase substrate specificity of assembly line polyketide synthases

9 September 2017

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Combinatorial biosynthesis of cyclic lipopeptide antibiotics: a model for synthetic biology to accelerate the evolution of secondary metabolite biosynthetic pathways

9 September 2017

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Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity

9 September 2017

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An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans

9 September 2017

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RNA-guided editing of bacterial genomes using CRISPR-Cas systems

9 September 2017

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Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs

9 September 2017

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9 September 2017

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2-Deoxystreptamine-containing aminoglycoside antibiotics: recent advances in the characterization and manipulation of their biosynthetic pathways

9 September 2017

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Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

9 September 2017

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Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.

9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity

9 September 2017

1 reference

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DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Organization of intracellular reactions with rationally designed RNA assemblies

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Biosynthesis of polyketides by trans-AT polyketide synthases

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

9 September 2017

1 reference

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Automated design of synthetic ribosome binding sites to control protein expression

9 September 2017

1 reference

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Synthetic protein scaffolds provide modular control over metabolic flux.

9 September 2017

1 reference

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Programming cells by multiplex genome engineering and accelerated evolution

9 September 2017

1 reference

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Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

9 September 2017

1 reference

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Drug discovery and natural products: end of an era or an endless frontier?

9 September 2017

1 reference

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The biosynthetic logic of polyketide diversity

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Enzymatic assembly of DNA molecules up to several hundred kilobases

9 September 2017

1 reference

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Recent advances in the biochemistry of spinosyns

9 September 2017

1 reference

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Metabolic engineering of microorganisms for isoprenoid production

9 September 2017

1 reference

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Crystal structure of the termination module of a nonribosomal peptide synthetase

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Cheminformatics analysis of natural products: lessons from nature inspiring the design of new drugs

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Combinatorial biosynthesis of novel antibiotics related to daptomycin

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

TAR cloning: insights into gene function, long-range haplotypes and genome structure and evolution

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Selective interaction between nonribosomal peptide synthetases is facilitated by short communication-mediating domains

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

The structure of docking domains in modular polyketide synthases

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Nonribosomal peptides: from genes to products

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Modular construction of a functional artificial epothilone polyketide pathway

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Heterologous expression and manipulation of three tetracycline biosynthetic pathways.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Complete reconstitution of a highly reducing iterative polyketide synthase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Structural rearrangements of a polyketide synthase module during its catalytic cycle

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

De novo biosynthesis of terminal alkyne-labeled natural products.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Biosynthetic multitasking facilitates thalassospiramide structural diversity in marine bacteria.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Engineered biosynthesis of novel polyketides

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Biosynthesis of antimycins with a reconstituted 3-formamidosalicylate pharmacophore in Escherichia coli.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Homology-integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Structure of a modular polyketide synthase

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Programming biological operating systems: genome design, assembly and activation

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Poly specific trans-acyltransferase machinery revealed via engineered acyl-CoA synthetases

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Sequential deletion of all the polyketide synthase and nonribosomal peptide synthetase biosynthetic gene clusters and a 900-kb subtelomeric sequence of the linear chromosome of Streptomyces coelicolor.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

SLIC: a method for sequence- and ligation-independent cloning.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Gene expression enabling synthetic diversification of natural products: chemogenetic generation of pacidamycin analogs

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Heterologous production of epothilone C and D in Escherichia coli.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757526

Production of ‘hybrid’ antibiotics by genetic engineering

20 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1893

Dissecting and exploiting intermodular communication in polyketide synthases

21 January 2018

1 reference

12 December 2020

Reprogramming nonribosomal peptide synthetases for "clickable" amino acids

1 reference

12 December 2020

Introduction of a non-natural amino acid into a nonribosomal peptide antibiotic by modification of adenylation domain specificity

1 reference

12 December 2020

DNA cloning by homologous recombination in Escherichia coli

1 reference

12 December 2020

Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1893

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26284672%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26284672%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference