Indecent exposure: when telomeres become uncapped (Q35632849)

9 August 2017

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title

Indecent exposure: when telomeres become uncapped (English)

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9 August 2017

Julia Promisel Cooper

series ordinal

3

object named as

Julia Promisel Cooper

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9 August 2017

Miguel Godinho Ferreira

series ordinal

1

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PubMed ID

14731390

9 August 2017

Kyle M Miller

series ordinal

2

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9 August 2017

1 January 2004

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9 August 2017

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9 August 2017

13

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9 August 2017

7-18

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9 August 2017

1

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Rap1p telomere association is not required for mitotic stability of a C(3)TA(2) telomere in yeast

9 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Strand-Specific Postreplicative Processing of Mammalian Telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Protection of telomeres by the Ku protein in fission yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Homologous recombination in human telomerase‐positive and ALT cells occurs with the same frequency

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomere maintenance in fission yeast requires an Est1 ortholog

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Cancer predisposition and hematopoietic failure in Rad50(S/S) mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

The Ku Heterodimer Performs Separable Activities at Double-Strand Breaks and Chromosome Termini

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomeric localization of TRF2, a novel human telobox protein

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Altering telomere structure allows telomerase to act in yeast lacking ATM kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Cdc13 both positively and negatively regulates telomere replication

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Regulation of telomere length and function by a Myb-domain protein in fission yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

A highly selective telomerase inhibitor limiting human cancer cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Est1 and Cdc13 as comediators of telomerase access

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

DNA-PKcs is critical for telomere capping

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

The Rad51 pathway of telomerase-independent maintenance of telomeres can amplify TG1-3 sequences in yku and cdc13 mutants of Saccharomyces cerevisiae.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Partners and pathwaysrepairing a double-strand break.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

End Resection Initiates Genomic Instability in the Absence of Telomerase

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomere dysfunction increases mutation rate and genomic instability

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Ku acts in a unique way at the mammalian telomere to prevent end joining

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Role of mammalian Rad54 in telomere length maintenance

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomere repeat binding factors: keeping the ends in check

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Senescence Induced by Altered Telomere State, Not Telomere Loss

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Targeted deletion reveals an essential function for the telomere length regulator Trf1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Essential role of mouse telomerase in highly proliferative organs

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Identification of human Rap1: implications for telomere evolution

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Ku86 is essential in human somatic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

NEJ1 prevents NHEJ-dependent telomere fusions in yeast without telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

POT1 as a terminal transducer of TRF1 telomere length control

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Clues to catastrophic telomere loss in mammals from yeast telomere rapid deletion

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomere fusions caused by mutating the terminal region of telomeric DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

The telomere protein Taz1 is required to prevent and repair genomic DNA breaks.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Circular chromosome formation in a fission yeast mutant defective in two ATM homologues.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomerase catalytic subunit homologs from fission yeast and human

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Two modes of survival of fission yeast without telomerase.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomere maintenance is dependent on activities required for end repair of double-strand breaks.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Cdc13 delivers separate complexes to the telomere for end protection and replication

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

The cellular response to DNA double-strand breaks: defining the sensors and mediators

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Alternative lengthening of telomeres, telomerase, and cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Stable inheritance of telomere chromatin structure and function in the absence of telomeric repeats

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Different telomere damage signaling pathways in human and mouse cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Erosion of the telomeric single-strand overhang at replicative senescence

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

DNA damage foci at dysfunctional telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

TRF2 Protects Human Telomeres from End-to-End Fusions

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Biochemical evidence for Ku-independent backup pathways of NHEJ

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Effects of double-strand break repair proteins on vertebrate telomere structure

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

Pif1p helicase, a catalytic inhibitor of telomerase in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900531-8

7 January 2021

10.1016/S1097-2765(03)00531-8

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

14731390