Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining (Q46531438)

22 December 2017

title

Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining (English)

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22 December 2017

2

Elizabeth H Blackburn

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22 December 2017

Simon W-L Chan

1

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22 December 2017

language of work or name

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1 May 2003

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22 December 2017

published in

Molecular Cell

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22 December 2017

volume

11

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22 December 2017

issue

5

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22 December 2017

page(s)

1379-1387

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22 December 2017

Telomere states and cell fates

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7 January 2021

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

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7 January 2021

Altering telomere structure allows telomerase to act in yeast lacking ATM kinases

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7 January 2021

Dominant Negative ATM Mutations in Breast Cancer Families

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'Marker swap' plasmids: convenient tools for budding yeast molecular genetics.

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Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.

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7 January 2021

Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere

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7 January 2021

MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae

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7 January 2021

Est1 and Cdc13 as comediators of telomerase access

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Identification of Kluyveromyces lactis telomerase: discontinuous synthesis along the 30-nucleotide-long templating domain

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Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint

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7 January 2021

ATM-dependent phosphorylation of nibrin in response to radiation exposure

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7 January 2021

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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7 January 2021

Reverse transcriptase motifs in the catalytic subunit of telomerase

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7 January 2021

Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase

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7 January 2021

Progressive cis-inhibition of telomerase upon telomere elongation.

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7 January 2021

Cell cycle restriction of telomere elongation

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7 January 2021

EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants

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Connecting chromosomes, crisis, and cancer

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Accelerated telomere shortening in ataxia telangiectasia

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7 January 2021

Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae

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7 January 2021

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

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7 January 2021

Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae

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7 January 2021

The telomerase reverse transcriptase: components and regulation

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7 January 2021

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

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7 January 2021

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

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7 January 2021

Functionally interacting telomerase RNAs in the yeast telomerase complex

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7 January 2021

Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro

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7 January 2021

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae

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7 January 2021

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

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7 January 2021

Est1p as a cell cycle-regulated activator of telomere-bound telomerase

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7 January 2021

The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres

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7 January 2021

Yeast DNA ligase IV mediates non-homologous DNA end joining

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7 January 2021

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

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7 January 2021

Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.

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7 January 2021

Human endothelial cell life extension by telomerase expression

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7 January 2021

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

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7 January 2021

The DNA damage response: putting checkpoints in perspective

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7 January 2021

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

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7 January 2021

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

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7 January 2021

10.1016/S1097-2765(03)00174-6

Identifiers

DOI

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22 December 2017

PubMed ID

12769860

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22 December 2017