DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2 (Q28509254)

24 January 2017

title

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2 (English)

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Ligase IV, DNA, ATP-dependent

24 January 2017

main subject

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GOA release 2020-03-11

author

Agata Smogorzewska

1

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Titia de Lange

object named as

Titia de Lange

5

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Jan Karlseder

2

object named as

Jan Karlseder

1 reference

24 January 2017

Heidi Holtgreve-Grez

3

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24 January 2017

Anna Jauch

4

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24 January 2017

publication date

1 October 2002

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24 January 2017

language of work or name

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24 January 2017

volume

12

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24 January 2017

issue

19

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24 January 2017

page(s)

1635–1644

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Extension of life-span by introduction of telomerase into normal human cells

24 January 2017

cites work

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The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

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Protection of mammalian telomeres

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TRF2 Protects Human Telomeres from End-to-End Fusions

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Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

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Strand-Specific Postreplicative Processing of Mammalian Telomeres

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7 January 2021

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

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Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells

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Ku acts in a unique way at the mammalian telomere to prevent end joining

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The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

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DNA-PKcs is critical for telomere capping

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Ku is associated with the telomere in mammals

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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

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Different telomere damage signaling pathways in human and mouse cells

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An optimized, fully automated system for fast and accurate identification of chromosomal rearrangements by multiplex-FISH (M-FISH).

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DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

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Normal human chromosomes have long G-rich telomeric overhangs at one end

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7 January 2021

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

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7 January 2021

The terminal DNA structure of mammalian chromosomes

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7 January 2021

Telomerase and DNA end replication: no longer a lagging strand problem?

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7 January 2021

Saccharomyces Ku70, Mre11/Rad50, and RPA Proteins Regulate Adaptation to G2/M Arrest after DNA Damage

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7 January 2021

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13

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7 January 2021

The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo

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7 January 2021

Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance

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7 January 2021

Conserved structure for single-stranded telomeric DNA recognition

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7 January 2021

Cdc13 delivers separate complexes to the telomere for end protection and replication

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7 January 2021

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7 January 2021

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7 January 2021

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Senescence Induced by Altered Telomere State, Not Telomere Loss

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7 January 2021

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7 January 2021