Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML (Q39260268)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23063124%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML (English)

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10 March 2020

1 reference

2

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10 March 2020

9

Anthony Letai

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10 March 2020

4

Donna Neuberg

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10 March 2020

author name string

Thanh-Trang Vo

1

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10 March 2020

Ruben Carrasco

3

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10 March 2020

Derrick J Rossi

5

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10 March 2020

Richard M Stone

6

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10 March 2020

Daniel J Deangelo

7

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10 March 2020

Mark G Frattini

8

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10 March 2020

publication date

1 October 2012

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10 March 2020

language of work or name

0 references

1 reference

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10 March 2020

volume

151

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10 March 2020

issue

2

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10 March 2020

page(s)

344-355

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Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

10 March 2020

cites work

1 reference

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Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

10 September 2017

1 reference

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Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

10 September 2017

1 reference

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Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.

10 September 2017

1 reference

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MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts

10 September 2017

1 reference

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Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

10 September 2017

1 reference

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Anthracycline dose intensification in acute myeloid leukemia

10 September 2017

1 reference

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Targeting DNA topoisomerase II in cancer chemotherapy

10 September 2017

1 reference

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Control of mitochondrial apoptosis by the Bcl-2 family

10 September 2017

1 reference

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BAX activation is initiated at a novel interaction site

10 September 2017

1 reference

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

10 September 2017

1 reference

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Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

10 September 2017

1 reference

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Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood

10 September 2017

1 reference

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Diagnosing and exploiting cancer's addiction to blocks in apoptosis

10 September 2017

1 reference

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

10 September 2017

1 reference

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

10 September 2017

1 reference

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

10 September 2017

1 reference

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Age and acute myeloid leukemia

10 September 2017

1 reference

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

10 September 2017

1 reference

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534747

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534747

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534747

Cytogenetics in acute leukemia

10 September 2017

1 reference

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Cell death: critical control points

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534747

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534747

Older adults with acute myeloid leukemia

10 September 2017

1 reference

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534747

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534747

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

10 September 2017

1 reference

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An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

10 September 2017

1 reference

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

10 September 2017

1 reference

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

10 September 2017

1 reference

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

10 September 2017

1 reference

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A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1).

15 June 2018

1 reference

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Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534747

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534747

Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23063124

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2012.08.038

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23063124%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

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10 March 2020

PubMed publication ID

23063124

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23063124%20AND%20SRC:MED&resulttype=core&format=json