BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells (Q36677926)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23333149%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells (English)

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22 February 2020

1 reference

1 reference

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7

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22 February 2020

Michael W Becker

13

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22 February 2020

11

Jane L Liesveld

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22 February 2020

author name string

Eleni D Lagadinou

1

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22 February 2020

Alexander Sach

2

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22 February 2020

Kevin Callahan

3

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22 February 2020

Randall M Rossi

4

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22 February 2020

Sarah J Neering

5

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22 February 2020

Mohammad Minhajuddin

6

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22 February 2020

Shanshan Pei

8

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22 February 2020

Valerie Grose

9

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22 February 2020

Kristen M O'Dwyer

10

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22 February 2020

Paul S Brookes

12

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22 February 2020

Craig T Jordan

14

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22 February 2020

language of work or name

English

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publication date

17 January 2013

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22 February 2020

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22 February 2020

volume

12

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22 February 2020

page(s)

329-341

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22 February 2020

issue

3

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Cancer stem cells: impact, heterogeneity, and uncertainty

22 February 2020

cites work

1 reference

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Metabolic state of glioma stem cells and nontumorigenic cells

30 September 2017

1 reference

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Energy metabolism in human pluripotent stem cells and their differentiated counterparts

30 September 2017

1 reference

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Regulation of cancer cell metabolism

30 September 2017

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Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice

30 September 2017

1 reference

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Mitochondrial fusion and fission in cell life and death

30 September 2017

1 reference

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The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

30 September 2017

1 reference

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Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML.

30 September 2017

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

30 September 2017

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

30 September 2017

1 reference

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Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

30 September 2017

1 reference

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A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

30 September 2017

1 reference

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Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells

30 September 2017

1 reference

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FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

30 September 2017

1 reference

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

30 September 2017

1 reference

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Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features

30 September 2017

1 reference

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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

30 September 2017

1 reference

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On the Origin of Cancer Cells

30 September 2017

1 reference

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Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell

30 September 2017

1 reference

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

30 September 2017

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Stem cell gene expression programs influence clinical outcome in human leukemia.

28 June 2018

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Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells

5 September 2018

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Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML).

5 September 2018

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bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23333149

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.STEM.2012.12.013

1 reference

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22 February 2020

1 reference

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22 February 2020

1 reference

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