IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism (Q36948088)

17 August 2017

IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism (English)

1 reference

17 August 2017

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755473%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Anne N. Murphy

18

1 reference

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31 May 2020

author name string

Alexandra R Grassian

1

1 reference

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31 May 2020

Seth J Parker

2

1 reference

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31 May 2020

Shawn M Davidson

3

1 reference

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31 May 2020

Ajit S Divakaruni

4

1 reference

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31 May 2020

Xiamei Zhang

6

1 reference

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31 May 2020

Kelly L Slocum

7

1 reference

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31 May 2020

Minying Pu

8

1 reference

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31 May 2020

Fallon Lin

9

1 reference

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31 May 2020

Chad Vickers

10

1 reference

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31 May 2020

Carol Joud-Caldwell

11

1 reference

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31 May 2020

Franklin Chung

12

1 reference

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31 May 2020

Hong Yin

13

1 reference

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31 May 2020

Erika D Handly

14

1 reference

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31 May 2020

Christopher Straub

15

1 reference

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31 May 2020

Joseph D Growney

16

1 reference

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31 May 2020

Matthew G Vander Heiden

17

1 reference

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31 May 2020

Raymond Pagliarini

19

1 reference

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31 May 2020

Christian M Metallo

20

1 reference

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31 May 2020

language of work or name

English

0 references

publication date

22 April 2014

1 reference

17 August 2017

1 reference

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31 May 2020

volume

74

1 reference

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31 May 2020

page(s)

3317-3331

1 reference

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31 May 2020

issue

12

1 reference

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Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo

31 May 2020

cites work

1 reference

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Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

29 September 2017

1 reference

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Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

29 September 2017

1 reference

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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

29 September 2017

1 reference

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An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

29 September 2017

1 reference

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Influence of metabolism on epigenetics and disease

29 September 2017

1 reference

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In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation

29 September 2017

1 reference

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Understanding metabolic regulation and its influence on cell physiology

29 September 2017

1 reference

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(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

29 September 2017

1 reference

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Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT).

29 September 2017

1 reference

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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

29 September 2017

1 reference

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Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

29 September 2017

1 reference

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Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation

29 September 2017

1 reference

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

29 September 2017

1 reference

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Frequent IDH1/2 mutations in intracranial chondrosarcoma: a possible diagnostic clue for its differentiation from chordoma

29 September 2017

1 reference

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Cancer-associated isocitrate dehydrogenase mutations

29 September 2017

1 reference

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Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

29 September 2017

1 reference

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IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping

29 September 2017

1 reference

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

29 September 2017

1 reference

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

29 September 2017

1 reference

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Reductive carboxylation supports growth in tumour cells with defective mitochondria.

29 September 2017

1 reference

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Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect

29 September 2017

1 reference

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Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

29 September 2017

1 reference

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

29 September 2017

1 reference

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

29 September 2017

1 reference

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Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

29 September 2017

1 reference

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

29 September 2017

1 reference

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

29 September 2017

1 reference

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Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

29 September 2017

1 reference

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13C metabolic flux analysis in complex systems.

29 September 2017

1 reference

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Recurring mutations found by sequencing an acute myeloid leukemia genome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

IDH1 and IDH2 mutations in gliomas

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

An integrated genomic analysis of human glioblastoma multiforme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

ATP citrate lyase inhibition can suppress tumor cell growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Integrated compound profiling screens identify the mitochondrial electron transport chain as the molecular target of the natural products manassantin, sesquicillin, and arctigenin

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885639

Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24755473

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-14-0772-T

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755473%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755473%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference