Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights (Q35009792)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25380750%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

review article

1 reference

title

Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights (English)

1 reference

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22 February 2020

4

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22 February 2020

author name string

Hyunho Yoon

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25380750%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Joshua P Dehart

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25380750%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

James M Murphy

series ordinal

3

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22 February 2020

publication date

7 November 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25380750%20AND%20SRC:MED&resulttype=core&format=json

Journal of Histochemistry and Cytochemistry

22 February 2020

published in

1 reference

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22 February 2020

volume

63

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22 February 2020

issue

2

1 reference

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22 February 2020

page(s)

114-128

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25380750%20AND%20SRC:MED&resulttype=core&format=json

FAK in cancer: mechanistic findings and clinical applications

22 February 2020

cites work

1 reference

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation

8 July 2018

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8 July 2018

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Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma

8 July 2018

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TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling.

8 July 2018

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Structural basis for the autoinhibition of focal adhesion kinase

8 July 2018

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8 July 2018

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Cellular characterization of a novel focal adhesion kinase inhibitor

8 July 2018

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8 July 2018

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8 July 2018

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Integrin-regulated FAK-Src signaling in normal and cancer cells

8 July 2018

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Organization and post-transcriptional processing of focal adhesion kinase gene

8 July 2018

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Overexpression of focal adhesion kinase in head and neck squamous cell carcinoma is independent of fak gene copy number.

8 July 2018

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Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells

8 July 2018

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Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.

8 July 2018

1 reference

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Crystal structure of the FERM domain of focal adhesion kinase.

8 July 2018

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FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation

8 July 2018

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Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

8 July 2018

1 reference

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Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53

8 July 2018

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Focal adhesion kinase: in command and control of cell motility

8 July 2018

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Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

8 July 2018

1 reference

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Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion

8 July 2018

1 reference

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Regulation of endothelial cell function BY FAK and PYK2.

8 July 2018

1 reference

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Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction

8 July 2018

1 reference

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Identification of a cancer stem cell in human brain tumors

8 July 2018

1 reference

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FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma

8 July 2018

1 reference

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Focal adhesion kinase: the first ten years

8 July 2018

1 reference

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Prospective identification of tumorigenic breast cancer cells

8 July 2018

1 reference

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The focal adhesion kinase--a regulator of cell migration and invasion

8 July 2018

1 reference

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v-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion

8 July 2018

1 reference

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Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression

8 July 2018

1 reference

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FAK integrates growth-factor and integrin signals to promote cell migration

8 July 2018

1 reference

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RAFTK/Pyk2-mediated cellular signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin-Darby canine kidney cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

8 July 2018

Focal adhesion kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Control of adhesion-dependent cell survival by focal adhesion kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Prostate cancer in a transgenic mouse

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

8 July 2018

1 reference

https://api.crossref.org/works/10.1369%2F0022155414561498

Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1369%2F0022155414561498

Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1369%2F0022155414561498

Clinical significance of focal adhesion kinase in resectable pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1369%2F0022155414561498

Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1369%2F0022155414561498

High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1369%2F0022155414561498

Identification of human pancreatic cancer stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1369%2F0022155414561498

Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1369%2F0022155414561498

The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1369%2F0022155414561498

Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4305513

[Expression and clinical significance of focal adhesion kinase in oral squamous cell carcinoma]

26 October 2018

1 reference

12 December 2020

Expression of focal adhesion kinase gene and invasive cancer

1 reference

12 December 2020

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1 reference

12 December 2020

The COOH-terminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells

1 reference

12 December 2020

A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability,

1 reference

12 December 2020

Clinical significance of high focal adhesion kinase gene copy number and overexpression in invasive breast cancer

1 reference

12 December 2020

Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes

1 reference

12 December 2020

[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]

1 reference

12 December 2020

Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells

1 reference

12 December 2020

Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland

1 reference

12 December 2020

Pathobiology of autochthonous prostate cancer in a pre‐clinical transgenic mouse model

1 reference

12 December 2020

The Janus protein tyrosine kinase family and its role in cytokine signaling

1 reference

12 December 2020

Identifiers

DOI

10.1369/0022155414561498

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/wczxrlksjffnxflfuahrsss2m4

30 July 2022

release_wczxrlksjffnxflfuahrsss2m4

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/wczxrlksjffnxflfuahrsss2m4

30 July 2022

https://api.fatcat.wiki/v0/release/wczxrlksjffnxflfuahrsss2m4

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/wczxrlksjffnxflfuahrsss2m4

1 reference

30 July 2022