The FERM domain: organizing the structure and function of FAK. (Q37802193)

23 August 2017

The FERM domain: organizing the structure and function of FAK. (English)

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23 August 2017

Daniel Lietha

4

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Margaret Frame

object named as

Margaret C Frame

series ordinal

1

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Bryan Serrels

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3

object named as

Bryan Serrels

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23 August 2017

Hitesh Patel

2

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PubMed ID

20966971

23 August 2017

Michael J Eck

series ordinal

5

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23 August 2017

1 November 2010

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Nature Reviews Molecular Cell Biology

23 August 2017

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23 August 2017

11

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23 August 2017

802-814

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23 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrm2996

23 August 2017

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Enlazin, a natural fusion of two classes of canonical cytoskeletal proteins, contributes to cytokinesis dynamics

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Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells

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FAK integrates growth-factor and integrin signals to promote cell migration

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RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers

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Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex

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A truncated FAK lacking the FERM domain displays high catalytic activity but retains responsiveness to adhesion-mediated signals

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Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions

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EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).

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Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition

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Direct Interaction of Focal Adhesion Kinase with p190RhoGEF

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An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase

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The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly

31 March 2020

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Focal adhesion kinase regulation of N-WASP subcellular localization and function

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Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development

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Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.

31 March 2020

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Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation.

31 March 2020

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A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity

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Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

31 March 2020

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Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

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Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase

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SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration

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Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

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Integrins and anoikis

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31 March 2020

1 reference

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

31 March 2020

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Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.

31 March 2020

1 reference

Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation

31 March 2020

1 reference

The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning

31 March 2020

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Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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The N-termini of FAK and JAKs contain divergent band 4.1 domains

31 March 2020

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FERM domain interaction promotes FAK signaling

31 March 2020

1 reference

The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology

31 March 2020

1 reference

Protein-tyrosine kinase CAKbeta/PYK2 is activated by binding Ca2+/calmodulin to FERM F2 alpha2 helix and thus forming its dimer

31 March 2020

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A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth

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Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion

31 March 2020

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Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src)

31 March 2020

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A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Talin concentrates to the midbody region during mammalian cell cytokinesis.

31 March 2020

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Suppression of hepatitis B viral gene expression by protein-tyrosine phosphatase PTPN3.

31 March 2020

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Subcellular localization and differentiation-induced redistribution of the protein tyrosine phosphatase PTP-BL in Neuroblastoma cells.

31 March 2020

1 reference

Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20966971

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20966971

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM2996

1 reference

PubMed ID

20966971

Dimensions Publication ID

23 August 2017

0 references

1 reference

PubMed ID

20966971