A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling (Q34863186)

5 August 2017

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title

A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling (English)

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5 August 2017

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Jie Chen

1

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PubMed ID

12234610

5 August 2017

Yimin Fang

series ordinal

2

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PubMed ID

12234610

5 August 2017

language of work or name

English

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publication date

1 October 2002

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5 August 2017

Biochemical Pharmacology

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5 August 2017

64

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5 August 2017

7

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5 August 2017

1071-1077

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Rapamycin eluting stent: the onset of a new era in interventional cardiology

5 August 2017

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PI 3-kinase, mTOR, protein synthesis and cancer

7 January 2021

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

7 January 2021

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Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

7 January 2021

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TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

7 January 2021

1 reference

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

7 January 2021

1 reference

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Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

7 January 2021

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Regulation of cellular growth by the Drosophila target of rapamycin dTOR

7 January 2021

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

7 January 2021

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

7 January 2021

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RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

7 January 2021

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7 January 2021

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TOR, a central controller of cell growth

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Regulation of translation initiation by FRAP/mTOR

7 January 2021

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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

7 January 2021

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Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

7 January 2021

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eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

7 January 2021

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

7 January 2021

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

7 January 2021

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

7 January 2021

1 reference

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Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation

7 January 2021

1 reference

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Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling

7 January 2021

1 reference

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Mammalian TOR: a homeostatic ATP sensor

7 January 2021

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

7 January 2021

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Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

7 January 2021

1 reference

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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

7 January 2021

1 reference

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Multiple independent inputs are required for activation of the p70 S6 kinase

7 January 2021

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Phosphatidic acid-mediated mitogenic activation of mTOR signaling

7 January 2021

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Messenger functions of phosphatidic acid

7 January 2021

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Regulation of phospholipase D.

7 January 2021

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Lysophosphatidic acid activates the 70-kDa S6 kinase via the lipoxygenase pathway

7 January 2021

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Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin

7 January 2021

1 reference

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Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

HEAT repeats mediate plasma membrane localization of Tor2p in yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

TOR2 is required for organization of the actin cytoskeleton in yeast

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

7 January 2021

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The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism

7 January 2021

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Mammalian phospholipase D structure and regulation

7 January 2021

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Expression of phospholipase D isoforms in mammalian cells

7 January 2021

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Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity.

7 January 2021

1 reference

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

7 January 2021

1 reference

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The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

7 January 2021

1 reference

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

7 January 2021

1 reference

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Translation control: connecting mitogens and the ribosome

7 January 2021

1 reference

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Regulation of phospholipase D by phosphorylation-dependent mechanisms.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Dual requirement for rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

An intracellular calcium signal activates p70 but not p90 ribosomal S6 kinase in liver epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Anionic phospholipids, interfacial binding and the regulation of cell functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Activation of phospholipase D by phosphatidic acid. Enhanced vesicle binding, phosphatidic acid-Ca2+ interaction, or an allosteric effect?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Properties and functions of diacylglycerol kinases

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

The structure and functions of human lysophosphatidic acid acyltransferases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Oncogenic kinase signalling

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901263-7

10.1016/S0006-2952(02)01263-7

7 January 2021

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12234610