Cell cycle regulatory E3 ubiquitin ligases as anticancer targets. (Q34170979)

31 July 2017

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title

Cell cycle regulatory E3 ubiquitin ligases as anticancer targets. (English)

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31 July 2017

Todd R Pray

1

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31 July 2017

Francesco Parlati

2

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31 July 2017

Jianing Huang

3

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31 July 2017

Brian R Wong

4

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31 July 2017

Donald G Payan

5

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31 July 2017

Mark K Bennett

6

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31 July 2017

Sarkiz Daniel Issakani

7

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31 July 2017

Susan Molineaux

8

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31 July 2017

Susan D Demo

9

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31 July 2017

1 December 2002

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31 July 2017

Drug Resistance Updates

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31 July 2017

5

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31 July 2017

6

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31 July 2017

249-258

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Proteasome inhibition: a novel approach to cancer therapy

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Hypophosphorylation of Mdm2 augments p53 stability

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Role of X-linked inhibitor of apoptosis protein in chemoresistance in ovarian cancer: possible involvement of the phosphoinositide-3 kinase/Akt pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Von Hippel-Lindau disease: clinical and molecular perspectives

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

SCF and Cullin/Ring H2-based ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Proteasome inhibitors as potential novel anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The MDM2 RING-finger domain is required to promote p53 nuclear export

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https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Cyclin is degraded by the ubiquitin pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Skp2 is oncogenic and overexpressed in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The anaphase-promoting complex: it's not just for mitosis any more.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

U box proteins as a new family of ubiquitin-protein ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Mdm2 promotes the rapid degradation of p53

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https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

MdmX protects p53 from Mdm2-mediated degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The SCF ubiquitin ligase: an extended look

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Crystal structure of the cyclin-specific ubiquitin-conjugating enzyme from clam, E2-C, at 2.0 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

NF-kappaB in cancer: from innocent bystander to major culprit

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The F-box protein family.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Regulation of APC activity by phosphorylation and regulatory factors

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The APC11 RING-H2 finger mediates E2-dependent ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Destabilizing influences in apoptosis: sowing the seeds of IAP destruction

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The MDM2 gene amplification database

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Identification of BIME as a subunit of the anaphase-promoting complex

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Mechanisms underlying ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

In search of the tumour-suppressor functions of BRCA1 and BRCA2

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Panepophenanthrin, from a Mushroom Strain, a Novel Inhibitor of the Ubiquitin-Activating Enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Waiting for anaphase: Mad2 and the spindle assembly checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Clinical cancer research 2001: new agents and therapies.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Whose end is destruction: cell division and the anaphase-promoting complex

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900121-8

7 January 2021

10.1016/S1368-7646(02)00121-8

Identifiers

DOI

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31 July 2017

1 reference