An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo (Q28144965)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10822382%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

title

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo (English)

1 reference

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6 November 2019

main subject

protein ubiquitination

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2

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6 November 2019

David P. Lane

7

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6 November 2019

author name string

C A Midgley

1

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6 November 2019

M K Saville

3

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6 November 2019

S Howard

4

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6 November 2019

A Sparks

5

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6 November 2019

R T Hay

6

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6 November 2019

publication date

1 May 2000

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6 November 2019

language of work or name

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6 November 2019

volume

19

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6 November 2019

issue

19

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6 November 2019

page(s)

2312-2323

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

6 November 2019

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Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

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Mapping of the p53 and mdm-2 Interaction Domains

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ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation

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E1A signaling to p53 involves the p19ARFtumor suppressor

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Ubch9 conjugates SUMO but not ubiquitin

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Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

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Mdm2 promotes the rapid degradation of p53

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

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Allosteric activation of latent p53 tetramers

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Small peptides activate the latent sequence-specific DNA binding function of p53.

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

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Regulation of p53 stability by Mdm2

21 January 2018

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An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

21 January 2018

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21 January 2018

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21 January 2018

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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7 January 2021

MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status

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7 January 2021

The CDKN2A (p16) gene and human cancer.

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7 January 2021

The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability

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7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

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7 January 2021

The p16INK4a/CDKN2A tumor suppressor and its relatives

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7 January 2021

Differential Regulation of the p21/WAF-1 and mdm2 Genes after High-Dose UV Irradiation: p53-Dependent and p53-Independent Regulation of the mdm2 Gene

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203593

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10822382%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 November 2019

1031554726

0 references

1 reference