Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 (Q22253350)

GOA release 2020-03-11

zinc ion binding

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GOA release 2020-03-11

S Fang

1

S

Fang

1 reference

8 February 2023

J P Jensen

2

J P

Jensen

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8 February 2023

R L Ludwig

3

R L

Ludwig

1 reference

8 February 2023

K H Vousden

4

K H

Vousden

1 reference

8 February 2023

A M Weissman

5

A M

Weissman

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Journal of Biological Chemistry

8 February 2023

publication date

24 March 2000

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language of work or name

English

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published in

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volume

275

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issue

12

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page(s)

8945-51

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cites work

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML

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7 January 2021

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

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Mechanisms of p53-mediated apoptosis

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7 January 2021

Functions of the MDM2 oncoprotein

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https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger

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https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Does this have a familiar RING?

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https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

MDM2 interacts with MDMX through their RING finger domains

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https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae

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7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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7 January 2021

PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism.

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7 January 2021

Photoreceptor Cell Differentiation Requires Regulated Proteolysis of the Transcriptional Repressor Tramtrack

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7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

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7 January 2021

TPEN, a Zn2+/Fe2+ chelator with low affinity for Ca2+, inhibits lamin assembly, destabilizes nuclear architecture and may independently protect nuclei from apoptosis in vitro

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https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

The RING finger domain: a recent example of a sequence-structure family

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https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

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7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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7 January 2021

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

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7 January 2021

Phosphatidylinositol 3-Phosphate Recognition by the FYVE Domain

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7 January 2021

Keeping an old friend under control: regulation of p53 stability

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7 January 2021

Sequential Metal Binding by the RING Finger Domain of BRCA1†

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7 January 2021

Metal and RNA binding properties of the hdm2 RING finger domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

p14ARF links the tumour suppressors RB and p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

p19ARF links the tumour suppressor p53 to Ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Praja1, a novel gene encoding a RING-H2 motif in mouse development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Mdm2 binds p73 alpha without targeting degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Regulation of p53 stability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Multi-site phosphorylation of p53 by protein kinases inducible by p53 and DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

The mouse and human genes encoding the recognition component of the N-end rule pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Identification of a family of closely related human ubiquitin conjugating enzymes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Yeast DNA Repair Proteins Rad6 and Rad18 Form a Heterodimer That Has Ubiquitin Conjugating, DNA Binding, and ATP Hydrolytic Activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

The RING finger motif of photomorphogenic repressor COP1 specifically interacts with the RING-H2 motif of a novel Arabidopsis protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Mammalian homologs of seven in absentia regulate DCC via the ubiquitin–proteasome pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Proteasomal regulation of nuclear receptor corepressor-mediated repression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

E1A signaling to p53 involves the p19ARFtumor suppressor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Tumor surveillance via the ARF–p53 pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

One ring to rule a superfamily of E3 ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Regulation of Mdm2-Directed Degradation by the C Terminus of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

MDM2 suppresses p73 function without promoting p73 degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

7 January 2021

https://api.crossref.org/works/10.1074%2FJBC.275.12.8945

1 reference

7 January 2021

Identifiers

DOI

10.1074/JBC.275.12.8945

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017