Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex (Q24294734)

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Stephen Elledge

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Joan W. Conaway

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Joan W Conaway

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author name string

Ning Zheng

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Brenda A Schulman

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Langzhou Song

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Julie J Miller

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Philip D Jeffrey

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Ping Wang

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Claire Chu

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Deanna M Koepp

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Ronald C Conaway

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J Wade Harper

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Nikola P Pavletich

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publication date

18 April 2002

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language of work or name

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416

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issue

6882

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page(s)

703-9

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SCF and Cullin/Ring H2-based ubiquitin ligases

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How the cyclin became a cyclin: regulated proteolysis in the cell cycle

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

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Role of the F-box protein Skp2 in lymphomagenesis

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Skp2 is oncogenic and overexpressed in human cancers

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Identification of the von Hippel-Lindau disease tumor suppressor gene

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

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Mechanisms underlying ubiquitination

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RING finger proteins: mediators of ubiquitin ligase activity

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

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A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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7 January 2021

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

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7 January 2021

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

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The F-box protein family.

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The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

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A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

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cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

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The von Hippel-Lindau tumor suppressor protein

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Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

1 reference

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Identification of a Cullin Homology Region in a Subunit of the Anaphase-Promoting Complex

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Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

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Crystal structure of the vesicular transport protein Sec17: implications for SNAP function in SNARE complex disassembly

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7 January 2021

Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins

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Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex

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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

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7 January 2021

The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation

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7 January 2021

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

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7 January 2021

Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1).

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7 January 2021

NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

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7 January 2021

The Nedd8-conjugated ROC1-CUL1 Core Ubiquitin Ligase Utilizes Nedd8 Charged Surface Residues for Efficient Polyubiquitin Chain Assembly Catalyzed by Cdc34

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7 January 2021

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

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7 January 2021

Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast

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7 January 2021

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

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7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

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7 January 2021

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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The CCP4 suite: programs for protein crystallography

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7 January 2021

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

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7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

7 January 2021

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin

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7 January 2021