Developmental defects and tumor predisposition in Rb mutant mice (Q33739263)

29 July 2017

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title

Developmental defects and tumor predisposition in Rb mutant mice (English)

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29 July 2017

Vooijs M

1

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29 July 2017

Berns A

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

1 September 1999

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29 July 2017

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29 July 2017

18

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29 July 2017

5293-5303

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29 July 2017

38

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1202999

29 July 2017

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cites work

Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Unscheduled DNA replication precedes apoptosis of photoreceptors expressing SV40 T antigen.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Cancer resistance genes in mice: models for the study of tumour modifiers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

p14ARF links the tumour suppressors RB and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Expression of a retinoblastoma transgene results in dwarf mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Retinoblastoma protein recruits histone deacetylase to repress transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Deletion of RB exons 24 and 25 causes low-penetrance retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Requirement for a functional Rb-1 gene in murine development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Shared role of the pRB-related p130 and p107 proteins in limb development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Loss of heterozygosity in normal tissue adjacent to breast carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

The regulation of E2F by pRB-family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Mortality from second tumors among long-term survivors of retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Tumour suppressor gene mutations in humans and mice: parallels and contrasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Is sunlight an aetiological agent in the genesis of retinoblastoma?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Tumor suppressor gene mutations in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Effects of an Rb mutation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Retinoblastoma and intracranial malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Mutation and cancer: statistical study of retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Inactivation of the retinoblastoma susceptibility gene in human breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Trilateral retinoblastoma: insights into histogenesis and management

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Growth suppression by p16ink4 requires functional retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Retinoblastoma gene mutations in primary human bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Second primary tumors in patients with retinoblastoma. A review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

The retinoblastoma gene family: cousins with overlapping interests.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Controlling your losses: conditional gene silencing in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Conditional gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

pRb and p107 regulate E2F activity during lens fiber cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Mutations of N-terminal regions render the retinoblastoma protein insufficient for functions in development and tumor suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

p107 is a suppressor of retinoblastoma development in pRb-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Retinoblastoma in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Cell differentiation in the retina of the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Inverse association between cyclin D1 overexpression and retinoblastoma gene mutation in thyroid carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

Trilateral retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Rods and cones in the mouse retina. II. Autoradiographic analysis of cell generation using tritiated thymidine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Mouse models in tumor suppression

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Speculations on the roles of RB1 in tissue-specific differentiation, tumor initiation, and tumor progression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Oncogene expression in retinal horizontal cells of transgenic mice results in a cascade of neurodegeneration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Genetic background alters the spectrum of tumors that develop in p53-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Characteristics of genomic breakpoints in TLS-CHOP translocations in liposarcomas suggest the involvement of Translin and topoisomerase II in the process of translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

All in the (cancer) family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Targeted disruption of p107: functional overlap between p107 and Rb

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

p53 regulates apoptosis in human retinoblastoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

The p16INK4a/CDKN2A tumor suppressor and its relatives.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Cooperative tumorigenic effects of germline mutations in Rb and p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Photoreceptor-specific activity of the human interphotoreceptor retinoid-binding protein (IRBP) promoter in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202999

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202999

1 reference

Dimensions Publication ID

29 July 2017

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1 reference