Geminin, an inhibitor of DNA replication, is degraded during mitosis (Q24309195)

negative regulation of cell cycle

GOA release 2020-03-11

1 reference

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle.

GOA release 2020-03-11

author name string

T J McGarry

series ordinal

1

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M W Kirschner

series ordinal

2

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language of work or name

English

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publication date

12 June 1998

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published in

Cell

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volume

93

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page(s)

1043-53

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issue

6

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cites work

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Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs

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A role for the nuclear envelope in controlling DNA replication within the cell cycle

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Role for a Xenopus Orc2-related protein in controlling DNA replication

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Purification of an MCM-containing complex as a component of the DNA replication licensing system.

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Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p

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7 January 2021

The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts

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7 January 2021

S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state.

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Cut2 proteolysis required for sister-chromatid seperation in fission yeast

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Cyclin is degraded by the ubiquitin pathway

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The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1

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DNA synthesis in a cell-free system from Xenopus eggs: Priming and elongation on single-stranded DNA in vitro

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7 January 2021

Topoisomerase II does not play a scaffolding role in the organization of mitotic chromosomes assembled in Xenopus egg extracts

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7 January 2021

Ubiquitin-dependent protein degradation

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7 January 2021

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor.

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7 January 2021

Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast

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7 January 2021

Early events in DNA replication require cyclin E and are blocked by p21CIP1.

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7 January 2021

APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle

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7 January 2021

A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

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How proteolysis drives the cell cycle

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Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates

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Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor

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The nuclear membrane prevents replication of human G2 nuclei but not G1 nuclei in Xenopus egg extract

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Predicting coiled coils from protein sequences

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Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development

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Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor

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Universal control mechanism regulating onset of M-phase

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Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast

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7 January 2021

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

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Chromatin proteins involved in the initiation of DNA replication.

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Interaction between the origin recognition complex and the replication licensing system in Xenopus.

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A quantitative model for the cdc2 control of S phase and mitosis in fission yeast

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Cell cycle control of DNA replication.

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7 January 2021

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

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7 January 2021

Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation

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7 January 2021