The functions and regulation of the PTEN tumour suppressor (Q29615536)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22473468

30 April 2017

author name string

Song MS

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1

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Salmena L

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2

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Pandolfi PP

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3

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22473468

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22473468

30 April 2017

language of work or name

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30 April 2017

publication date

4 April 2012

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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13

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page(s)

283-96

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issue

5

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Patterns of the early, gross chromosomal changes in malignant human gliomas.

30 April 2017

cites work

1 reference

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

31 March 2020

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

31 March 2020

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Pten is essential for embryonic development and tumour suppression

31 March 2020

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

31 March 2020

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

31 March 2020

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Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

31 March 2020

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Impaired Fas response and autoimmunity in Pten+/- mice

31 March 2020

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Subtle variations in Pten dose determine cancer susceptibility

31 March 2020

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A continuum model for tumour suppression

31 March 2020

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Mutation and cancer: statistical study of retinoblastoma

31 March 2020

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

31 March 2020

1 reference

Form and function in protein dephosphorylation

31 March 2020

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

31 March 2020

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Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

31 March 2020

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Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

31 March 2020

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AKT/PKB signaling: navigating downstream

31 March 2020

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mTOR: from growth signal integration to cancer, diabetes and ageing

31 March 2020

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Defining the role of mTOR in cancer

31 March 2020

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

31 March 2020

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Molecular mechanisms of mTOR-mediated translational control

31 March 2020

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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

31 March 2020

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Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

31 March 2020

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4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

31 March 2020

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Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

31 March 2020

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

31 March 2020

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

31 March 2020

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

31 March 2020

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Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

31 March 2020

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Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

31 March 2020

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

31 March 2020

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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

31 March 2020

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Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

31 March 2020

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Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events

31 March 2020

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Tenets of PTEN tumor suppression

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

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Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein

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Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

31 March 2020

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Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.

31 March 2020

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Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

31 March 2020

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The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway

31 March 2020

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Tumours with PI3K activation are resistant to dietary restriction

31 March 2020

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Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

31 March 2020

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

31 March 2020

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PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

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The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

31 March 2020

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Pten in stromal fibroblasts suppresses mammary epithelial tumours

31 March 2020

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31 March 2020

Fibroblasts in cancer

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Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320

31 March 2020

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Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

31 March 2020

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Distinct epigenetic changes in the stromal cells of breast cancers

31 March 2020

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Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

31 March 2020

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A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

31 March 2020

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

31 March 2020

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Differential requirement of mTOR in postmitotic tissues and tumorigenesis

31 March 2020

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p19ARF links the tumour suppressor p53 to Ras

31 March 2020

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Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

31 March 2020

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Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

31 March 2020

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The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory

31 March 2020

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SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

31 March 2020

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Pro-senescence therapy for cancer treatment

31 March 2020

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Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

31 March 2020

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In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics

31 March 2020

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

31 March 2020

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

31 March 2020

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A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell

31 March 2020

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mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.

31 March 2020

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Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

31 March 2020

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Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

31 March 2020

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Essential role for nuclear PTEN in maintaining chromosomal integrity

31 March 2020

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Lack of PTEN sequesters CHK1 and initiates genetic instability.

31 March 2020

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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

31 March 2020

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PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

31 March 2020

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PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors

31 March 2020

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Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation

31 March 2020

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PTEN, more than the AKT pathway

31 March 2020

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Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

31 March 2020

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Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.

31 March 2020

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Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor

31 March 2020

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Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway

31 March 2020

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CREB is a novel nuclear target of PTEN phosphatase

31 March 2020

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Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

31 March 2020

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PTEN loss in the continuum of common cancers, rare syndromes and mouse models.

31 March 2020

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PTEN: one gene, many syndromes

31 March 2020

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Ubiquitination regulates PTEN nuclear import and tumor suppression

31 March 2020

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Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway

31 March 2020

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Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex

31 March 2020

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Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer

31 March 2020

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Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis

31 March 2020

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Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition

31 March 2020

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Regulation of PTEN transcription by p53

31 March 2020

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Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.

31 March 2020

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CBF-1 (RBP-J kappa) binds to the PTEN promoter and regulates PTEN gene expression

31 March 2020

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c-Jun promotes cellular survival by suppression of PTEN.

31 March 2020

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Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway

31 March 2020

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Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

31 March 2020

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The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

31 March 2020

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MicroRNAs: target recognition and regulatory functions

31 March 2020

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Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

31 March 2020

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miR-19 is a key oncogenic component of mir-17-92

31 March 2020

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Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

31 March 2020

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MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

31 March 2020

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Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis.

31 March 2020

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Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas

31 March 2020

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A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

31 March 2020

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A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?

31 March 2020

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In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma

31 March 2020

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An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma

31 March 2020

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Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

31 March 2020

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p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.

31 March 2020

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Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

31 March 2020

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Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation

31 March 2020

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Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta

31 March 2020

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Regulation of PTEN stability and activity by Plk3

31 March 2020

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Regulation of PTEN by Rho small GTPases

31 March 2020

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Rak functions as a tumor suppressor by regulating PTEN protein stability and function

31 March 2020

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NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

31 March 2020

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PCAF modulates PTEN activity

31 March 2020

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SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells

31 March 2020

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Reversible inactivation of the tumor suppressor PTEN by H2O2

31 March 2020

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PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

31 March 2020

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Txnip balances metabolic and growth signaling via PTEN disulfide reduction

31 March 2020

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Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

31 March 2020

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E3 ligase Nedd4 promotes axon branching by downregulating PTEN

31 March 2020

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The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

31 March 2020

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X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

31 March 2020

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WWP2 is an E3 ubiquitin ligase for PTEN.

31 March 2020

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Protein interactions of phosphatase and tensin homologue (PTEN) and its cancer-associated G20E mutant compared by using stable isotope labeling by amino acids in cell culture-based parallel affinity purification

31 March 2020

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The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

31 March 2020

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PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling

31 March 2020

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PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

31 March 2020

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Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins.

31 March 2020

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Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

31 March 2020

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MyosinV controls PTEN function and neuronal cell size.

31 March 2020

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Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination

31 March 2020

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Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

31 March 2020

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The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling

31 March 2020

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DJ-1, a novel regulator of the tumor suppressor PTEN.

31 March 2020

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Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

31 March 2020

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Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells.

31 March 2020

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α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells

31 March 2020

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

31 March 2020

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The emerging mechanisms of isoform-specific PI3K signalling

31 March 2020

1 reference

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.

31 March 2020

1 reference

PKB/AKT: functional insights from genetic models

31 March 2020

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

31 March 2020

1 reference

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.

31 March 2020

1 reference

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease.

31 March 2020

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Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines

31 March 2020

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Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

31 March 2020

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Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

31 March 2020

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Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

31 March 2020

1 reference

On respiratory impairment in cancer cells

31 March 2020

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12 December 2020

The Catalogue of Somatic Mutations in Cancer (COSMIC)

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12 December 2020

Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN.

1 reference

12 December 2020

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

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12 December 2020

Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

1 reference

12 December 2020

Differential p53-independent outcomes of p19(Arf) loss in oncogenesis

1 reference

12 December 2020

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

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498145

1040868228

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498145

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22473468

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017