Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association (Q27620298)

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1 November 2019

title

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association (English)

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1 November 2019

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Antonio Di Cristofano

4

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1 November 2019

Tomohiko Maehama

5

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J E Dixon

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1 November 2019

author name string

J O Lee

1

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1 November 2019

H Yang

2

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1 November 2019

M M Georgescu

3

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Y Shi

6

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1 November 2019

P Pandolfi

8

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1 November 2019

N P Pavletich

9

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1 November 2019

language of work or name

English

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publication date

1 October 1999

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1 November 2019

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1 November 2019

volume

99

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1 November 2019

page(s)

323-334

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1 November 2019

issue

3

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1 November 2019

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Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate

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Crystal structure of human protein tyrosine phosphatase 1B

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A structure-function study of the C2 domain of cytosolic phospholipase A2. Identification of essential calcium ligands and hydrophobic membrane binding residues.

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Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.

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Pten is essential for embryonic development and tumour suppression

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Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

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A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1

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Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV

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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

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Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

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Improved methods for building protein models in electron density maps and the location of errors in these models

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

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7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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7 January 2021

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

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7 January 2021

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

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7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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7 January 2021

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

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7 January 2021

Crystal structure of the C2 domain from protein kinase C-delta

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7 January 2021

Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2

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7 January 2021

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

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7 January 2021

C2-domains, structure and function of a universal Ca2+-binding domain

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Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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7 January 2021

Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

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Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

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Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

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Crystal structure of the dual specificity protein phosphatase VHR

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Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

1685348

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1 November 2019

1685348

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

1685348