Molecular mechanisms of mTOR-mediated translational control (Q29615529)

Europe PubMed Central

title

Molecular mechanisms of mTOR-mediated translational control (English)

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30 April 2017

author name string

Ma XM

series ordinal

1

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Blenis J

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2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19339977

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language of work or name

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30 April 2017

publication date

May 2009

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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volume

10

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page(s)

307-18

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issue

5

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Translational control in vertebrate development

30 April 2017

cites work

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Biochemical mechanisms for translational regulation in synaptic plasticity

31 March 2020

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Local translational control in dendrites and its role in long-term synaptic plasticity

31 March 2020

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Translational control in stress and apoptosis

31 March 2020

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Translational control of gene expression and disease

31 March 2020

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Does the ribosome translate cancer?

31 March 2020

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Translation matters: protein synthesis defects in inherited disease

31 March 2020

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Cell-free translation reconstituted with purified components

31 March 2020

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Molecular mechanisms of translation initiation in eukaryotes

31 March 2020

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Molecular mechanisms of translational control

31 March 2020

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eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

31 March 2020

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Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

31 March 2020

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Translational controls impinging on the 5'-untranslated region and initiation factor proteins

31 March 2020

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Regulation of mRNA translation by 5'- and 3'-UTR-binding factors

31 March 2020

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eIF4A: the godfather of the DEAD box helicases

31 March 2020

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

31 March 2020

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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

31 March 2020

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TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals

31 March 2020

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Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

31 March 2020

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Tor signalling in bugs, brain and brawn

31 March 2020

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Identification of a conserved motif required for mTOR signaling

31 March 2020

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TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

31 March 2020

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Rheb fills a GAP between TSC and TOR.

31 March 2020

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Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

31 March 2020

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Upstream and downstream of mTOR

31 March 2020

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mTOR, translational control and human disease.

31 March 2020

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Defining the role of mTOR in cancer

31 March 2020

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mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer

31 March 2020

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Translational control: the cancer connection

31 March 2020

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

31 March 2020

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

31 March 2020

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

31 March 2020

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Akt regulates growth by directly phosphorylating Tsc2

31 March 2020

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

31 March 2020

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

31 March 2020

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Tsc2 is not a critical target of Akt during normal Drosophila development

31 March 2020

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

31 March 2020

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

31 March 2020

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

31 March 2020

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The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

31 March 2020

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PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

31 March 2020

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Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

31 March 2020

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A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

31 March 2020

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Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

31 March 2020

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

31 March 2020

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

31 March 2020

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Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

31 March 2020

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IRS-1: auditing the effectiveness of mTOR inhibitors

31 March 2020

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Regulation of transcription by MAP kinase cascades

31 March 2020

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MAPK signal specificity: the right place at the right time

31 March 2020

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Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

31 March 2020

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Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

31 March 2020

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The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells

31 March 2020

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Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

31 March 2020

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

31 March 2020

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Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

31 March 2020

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

31 March 2020

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Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.

31 March 2020

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Signalling by CD95 and TNF receptors: not only life and death.

31 March 2020

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The IkappaB kinase - a bridge between inflammation and cancer

31 March 2020

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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

31 March 2020

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M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase

31 March 2020

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IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

31 March 2020

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Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha

31 March 2020

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Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt.

31 March 2020

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Mammalian TOR: a homeostatic ATP sensor

31 March 2020

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

31 March 2020

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TSC2 mediates cellular energy response to control cell growth and survival

31 March 2020

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Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.

31 March 2020

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

31 March 2020

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The LKB1 tumor suppressor negatively regulates mTOR signaling

31 March 2020

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

31 March 2020

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Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?

31 March 2020

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Hypoxia-induced energy stress regulates mRNA translation and cell growth

31 March 2020

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A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

31 March 2020

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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

31 March 2020

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31 March 2020

Expanding mTOR signaling

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The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

31 March 2020

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

31 March 2020

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Regulation of TORC1 by Rag GTPases in nutrient response

31 March 2020

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mTOR signaling: RAG GTPases transmit the amino acid signal

31 March 2020

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Regulation of translation initiation by FRAP/mTOR

31 March 2020

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Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function.

31 March 2020

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mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

31 March 2020

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PI3-kinase and TOR: PIKTORing cell growth

31 March 2020

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Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

31 March 2020

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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

31 March 2020

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

31 March 2020

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

31 March 2020

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Specific hydrolysis of rabbit globin messenger RNA by S1 nuclease

31 March 2020

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Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

31 March 2020

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14-3-3sigma controls mitotic translation to facilitate cytokinesis

31 March 2020

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The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation

31 March 2020

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A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A

31 March 2020

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

31 March 2020

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SKAR is a specific target of S6 kinase 1 in cell growth control

31 March 2020

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SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs

31 March 2020

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The ever-increasing complexities of the exon junction complex

31 March 2020

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EJCs at the heart of translational control

31 March 2020

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The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1.

31 March 2020

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The gene encoding the splicing factor SF2/ASF is a proto-oncogene

31 March 2020

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Following translation by single ribosomes one codon at a time.

31 March 2020

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

31 March 2020

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

31 March 2020

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

31 March 2020

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

31 March 2020

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

31 March 2020

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

31 March 2020

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

31 March 2020

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

31 March 2020

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mTOR signaling: implications for cancer and anticancer therapy

31 March 2020

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The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

31 March 2020

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The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL

31 March 2020

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Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis

31 March 2020

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Regulation of peptide-chain elongation in mammalian cells

31 March 2020

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cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner

31 March 2020

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Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification

31 March 2020

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12 December 2020

The Secondary Structure and Poly(A) Content of Globin Messenger RNA as a Pure RNA and in Polyribosome-Derived Ribonucleoprotein Complexes

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12 December 2020

Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways.

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12 December 2020

Wnt/beta-catenin pathway

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12 December 2020

The RSK factors of activating the Ras/MAPK signaling cascade

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12 December 2020

mTOR Signaling to Translation

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12 December 2020

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Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

204096

1009809325

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204096

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19339977

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30 April 2017

Consolidated OpenCitations Corpus – April 2017