Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors (Q36042091)

11 August 2017

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors (English)

1 reference

11 August 2017

Christopher J Lord

8

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Alan Ashworth

9

object named as

Alan Ashworth

1 reference

11 August 2017

3

Rachel Brough

1 reference

11 August 2017

4

Afshan McCarthy

1 reference

11 August 2017

1

Ana M Mendes-Pereira

1 reference

11 August 2017

Sarah A Martin

2

1 reference

11 August 2017

Jessica R Taylor

5

1 reference

11 August 2017

Jung-Sik Kim

6

1 reference

11 August 2017

Todd Waldman

7

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11 August 2017

1 September 2009

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11 August 2017

language of work or name

English

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published in

EMBO Molecular Medicine

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11 August 2017

1

1 reference

11 August 2017

6-7

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11 August 2017

315-322

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

The role of PTEN signaling perturbations in cancer and in targeted therapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Understanding PTEN regulation: PIP2, polarity and protein stability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Tenets of PTEN tumor suppression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Resistance to therapy caused by intragenic deletion in BRCA2

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Activated PI3K signaling as an endogenous inducer of p53 in human cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Essential role for nuclear PTEN in maintaining chromosomal integrity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Ubiquitination regulates PTEN nuclear import and tumor suppression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

The concept of synthetic lethality in the context of anticancer therapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Molecular views of recombination proteins and their control

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Chemically targeting the PI3K family

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378149

Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FEMMM.200900041

Exploiting the DNA Repair Defect in BRCA Mutant Cells in the Design of New Therapeutic Strategies for Cancer

21 January 2018

1 reference

12 December 2020

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

1 reference

12 December 2020

Combining carefully selected drug, patient genetics may lead to total tumor death

1 reference

12 December 2020

Expression and prognostic significance of PTEN product protein in patients with esophageal squamous cell carcinoma

1 reference

12 December 2020

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FEMMM.200900041

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/EMMM.200900041

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

20049735

1 reference