Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation (Q28477043)

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English	Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation	scientific article

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Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation (English)

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Michael K Lee

9

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Valina L. Dawson

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Valina L Dawson

7

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8

object named as

Ted M Dawson

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author name string

Bobby Thomas

1

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Allen S Mandir

2

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Neva West

3

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Ying Liu

4

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Shaida A Andrabi

5

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Wanda Stirling

6

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publication date

31 January 2011

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6

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1

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e16706

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copyright license

Creative Commons Attribution 4.0 International

31 January 2011

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April 2022 Public Data File from Crossref

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Mice lacking alpha-synuclein are resistant to mitochondrial toxins

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An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

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Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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19 March 2017

alpha-Synuclein locus triplication causes Parkinson's disease

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19 March 2017

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

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Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice

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Alpha-synuclein in Lewy bodies

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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19 March 2017

Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice

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19 March 2017

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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19 March 2017

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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7 April 2017

Parkinson's disease: mechanisms and models

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7 April 2017

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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7 April 2017

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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7 April 2017

A Drosophila model of Parkinson's disease

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Parkinson's disease. First of two parts

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Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

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Oxidative stress alters the regulatory control of p66Shc and Akt in PINK1 deficient cells.

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29 September 2017

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.

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29 September 2017

Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

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29 September 2017

A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL/6J mouse

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29 September 2017

MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity

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29 September 2017

Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra

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29 September 2017

Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease

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29 September 2017

Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression

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29 September 2017

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

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Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

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29 September 2017

Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

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Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.

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29 September 2017

Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease

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29 September 2017

Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide

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29 September 2017

Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease

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29 September 2017

Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease

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Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

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Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

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Pathophysiology of Parkinson's disease: from clinical neurology to basic neuroscience and back

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29 September 2017

beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

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Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease

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The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety

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29 September 2017

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

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New stereological methods for counting neurons

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Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

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Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals.

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Parkinson's disease

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Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

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21 January 2018

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease

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Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

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Overexpression of Parkinson's disease-associated alpha-synucleinA53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP.

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Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

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Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration

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Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP.

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Age-related severity of dopaminergic neurodegeneration to MPTP neurotoxicity causes motor dysfunction in C57BL/6 mice.

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Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice

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Fluoxetine and desipramine selectively attenuate 2'-NH2-MPTP-induced depletions in serotonin and norepinephrine.

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An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model

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21 January 2018

Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice

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Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

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2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin

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Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

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Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0016706

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Consolidated OpenCitations Corpus – April 2017

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2011PLoSO...616706T

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

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