Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP. (Q44802800)

6 December 2017

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP. (English)

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6 December 2017

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4

Edward Rockenstein

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6 December 2017

5

Eliezer Masliah

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6 December 2017

David D Song

1

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6 December 2017

Clifford W Shults

series ordinal

2

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6 December 2017

Abbyann Sisk

series ordinal

3

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6 December 2017

language of work or name

English

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publication date

1 April 2004

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6 December 2017

Experimental Neurology

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6 December 2017

186

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6 December 2017

158-172

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6 December 2017

2

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

6 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss.

7 January 2021

1 reference

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Dendritic release of dopamine in the substantia nigra

7 January 2021

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Developmental cell death: morphological diversity and multiple mechanisms

7 January 2021

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

7 January 2021

1 reference

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Abnormal patterns of microtubule-associated protein-2 (MAP-2) immunolabeling in neuronal nuclei and Lewy bodies in Parkinson's disease substantia nigra brain tissues.

7 January 2021

1 reference

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Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration

7 January 2021

1 reference

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Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

7 January 2021

1 reference

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A Drosophila model of Parkinson's disease

7 January 2021

1 reference

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Neuropathologic features of Parkinson's, Huntington's, and Alzheimer's diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

An electron microscopic study of MPTP-induced inclusion bodies in an old monkey

7 January 2021

1 reference

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In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies

7 January 2021

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Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man.

7 January 2021

1 reference

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PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease

7 January 2021

1 reference

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Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

7 January 2021

1 reference

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Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease

7 January 2021

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

7 January 2021

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The relationships between aging, monoamine oxidase, striatal dopamine and the effects of MPTP in C57BL/6 mice: a critical reassessment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

7 January 2021

1 reference

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Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

7 January 2021

1 reference

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The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

7 January 2021

1 reference

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The rat brain synucleins; family of proteins transiently associated with neuronal membrane

7 January 2021

1 reference

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat

7 January 2021

1 reference

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The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons

7 January 2021

1 reference

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Etiology and pathogenesis of Parkinson's disease

7 January 2021

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The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

7 January 2021

1 reference

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Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.

7 January 2021

1 reference

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Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium.

7 January 2021

1 reference

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

7 January 2021

1 reference

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The nigrostriatal pathway in the rat: A single-axon study of the relationship between dorsal and ventral tier nigral neurons and the striosome/matrix striatal compartments.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

7 January 2021

1 reference

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Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

7 January 2021

1 reference

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Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

7 January 2021

1 reference

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Ultrastructural observations in Parkinsonism

7 January 2021

1 reference

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Mitochondrial complex I deficiency in Parkinson's disease

7 January 2021

1 reference

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alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

The influence of dose and dosing interval on MPTP-induced dopaminergic neurotoxicity in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Alpha-synuclein in Lewy bodies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Time course of MPTP-induced degeneration of the nigrostriatal dopamine system in C57 BL/6 mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Neuropathological study on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of the crab-eating monkey.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Neuropathology in mice expressing human alpha-synuclein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

Glutamate receptor binding sites in MPTP-treated mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4886%2803%2900342-X

10.1016/S0014-4886(03)00342-X

7 January 2021

Identifiers

DOI

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6 December 2017

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