Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. (Q43940212)

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8 December 2019

title

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system (English)

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8 December 2019

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8

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8 December 2019

author name string

Deniz Kirik

1

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8 December 2019

Carl Rosenblad

2

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8 December 2019

Corinna Burger

3

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8 December 2019

Cecilia Lundberg

4

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8 December 2019

Teit E Johansen

5

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8 December 2019

Nicholas Muzyczka

6

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8 December 2019

Ronald J Mandel

7

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8 December 2019

language of work or name

English

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publication date

1 April 2002

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8 December 2019

published in

Journal of Neuroscience

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8 December 2019

volume

22

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8 December 2019

page(s)

2780-2791

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8 December 2019

issue

7

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

8 December 2019

cites work

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12 December 2020

The ubiquitin pathway in Parkinson's disease.

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12 December 2020

Pathoanatomy of Parkinson's disease

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Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

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Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and Cap

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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12 December 2020

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

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12 December 2020

Neuropathology of synuclein aggregates

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12 December 2020

A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease

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12 December 2020

alpha-synuclein promotes mitochondrial deficit and oxidative stress

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12 December 2020

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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12 December 2020

CMV-beta-actin promoter directs higher expression from an adeno-associated viral vector in the liver than the cytomegalovirus or elongation factor 1 alpha promoter and results in therapeutic levels of human factor X in mice

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12 December 2020

Neuropathology in mice expressing human alpha-synuclein

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12 December 2020

Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model

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12 December 2020

Alpha-synuclein in Lewy bodies

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12 December 2020

Adeno-associated virus general transduction vectors: analysis of proviral structures

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12 December 2020

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

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12 December 2020

Effects of dopaminergic agonists and antagonists of feeding in intact and 6-hydroxydopamine-treated rats.

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12 December 2020

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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12 December 2020

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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12 December 2020

Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors

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12 December 2020

Functional activity of substantia nigra grafts reinnervating the striatum: neurotransmitter metabolism and [14C]2-deoxy-D-glucose autoradiography

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12 December 2020

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

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12 December 2020

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12 December 2020

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

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12 December 2020

Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat.

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12 December 2020

Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

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12 December 2020

Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

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12 December 2020

Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

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12 December 2020

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

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12 December 2020

An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism.

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12 December 2020

Somatosensory inattention after dopamine-depleting intracerebral 6-OHDA injections: Spontaneous recovery and pharmacological control

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12 December 2020

Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.

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12 December 2020

Failure of the ubiquitin-proteasome system in Parkinson's disease

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12 December 2020

A rapid and sensitive assay for tyrosine-3-monooxygenase based upon the release of 3H2O and adsorption of [3H]-tyrosine by charcoal

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12 December 2020

Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

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12 December 2020

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

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12 December 2020

Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian Cells

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12 December 2020

Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by instrastriatal 6-hydroxydopamine in the rat

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12 December 2020

Compensations after lesions of central dopaminergic neurons: some clinical and basic implications

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12 December 2020

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity.

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12 December 2020

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

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12 December 2020

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

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12 December 2020

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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12 December 2020

A Drosophila model of Parkinson's disease

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12 December 2020

10.1523/JNEUROSCI.22-07-02780.2002

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11923443%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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8 December 2019

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