A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling (Q40252247)

18 September 2017

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling (English)

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18 September 2017

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Edward A Fon

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Lara Fallon

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Catherine M L Bélanger

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Amadou T Corera

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Maria Kontogiannea

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Elsa Regan-Klapisz

5

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18 September 2017

France Moreau

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Jarno Voortman

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Michael Haber

8

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Geneviève Rouleau

9

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18 September 2017

Thorhildur Thorarinsdottir

10

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18 September 2017

Alexis Brice

11

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Paul M P van Bergen En Henegouwen

12

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18 September 2017

23 July 2006

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834-842

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https://scigraph.springernature.com/pub.10.1038/ncb1441

18 September 2017

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cites work

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

1 reference

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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Molecular pathophysiology of Parkinson's disease

21 January 2018

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Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

21 January 2018

1 reference

Clathrin-independent endocytosis of ubiquitinated cargos

21 January 2018

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c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15.

21 January 2018

1 reference

Regulation of ubiquitin-binding proteins by monoubiquitination

21 January 2018

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Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

21 January 2018

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21 January 2018

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Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

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Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

21 January 2018

1 reference

Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function

21 January 2018

1 reference

Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a

21 January 2018

1 reference

Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a

21 January 2018

1 reference

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

21 January 2018

1 reference

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

21 January 2018

1 reference

A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination

21 January 2018

1 reference

When ubiquitin meets ubiquitin receptors: a signalling connection

21 January 2018

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eps15, a novel tyrosine kinase substrate, exhibits transforming activity

21 January 2018

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Epidermal growth factor induces ubiquitination of Eps15.

21 January 2018

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Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27

21 January 2018

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Alterations in the common fragile site gene Parkin in ovarian and other cancers

21 January 2018

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Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

21 January 2018

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Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference

21 January 2018

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Receptor downregulation and multivesicular-body sorting

21 January 2018

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Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization.

21 January 2018

1 reference

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

21 January 2018

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EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans

21 January 2018

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Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons

21 January 2018

1 reference

DJ-1, a novel regulator of the tumor suppressor PTEN.

21 January 2018

1 reference

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

21 January 2018

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Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

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A susceptibility gene for late-onset idiopathic Parkinson's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/NCB1441

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18 September 2017

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