Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice (Q44430640)

2 December 2017

Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice (English)

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2 December 2017

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parkinsonian syndrome

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6

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2 December 2017

7

Südhof TC

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2 December 2017

Schlüter OM

1

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2 December 2017

Fornai F

2

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2 December 2017

Alessandrí MG

3

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2 December 2017

Takamori S

4

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2 December 2017

Geppert M

5

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2 December 2017

language of work or name

English

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publication date

1 January 2003

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2 December 2017

18

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published in

Neuroscience

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2 December 2017

118

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2 December 2017

4

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2 December 2017

985-1002

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

2 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Peripheral nervous system-specific genes identified by subtractive cDNA cloning

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Persyn, a member of the synuclein family, has a distinct pattern of expression in the developing nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain

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https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Binding of Rab3A to Synaptic Vesicles

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https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

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https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Synucleins in synaptic plasticity and neurodegenerative disorders

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https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Synthetic filaments assembled from C-terminally truncated alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

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https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

MPP(+)-induced neurotoxicity in mouse is age-dependent: evidenced by the selective inhibition of complexes of electron transport.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Alpha-synuclein and the Lewy body disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

A Drosophila model of Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Effects of pretreatment with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on methamphetamine pharmacokinetics and striatal dopamine losses

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Striatal dopamine metabolism in monoamine oxidase B-deficient mice: a brain dialysis study

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https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Neuropathology of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Multiple-system atrophy: a new alpha-synuclein disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Alpha-synuclein and neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Insights from mouse models into the molecular basis of neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Analysis of VMAT2 binding after methamphetamine or MPTP treatment: disparity between homogenates and vesicle preparations.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

A 38,000-dalton membrane protein (p38) present in synaptic vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Manganese superoxide dismutase overexpression attenuates MPTP toxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Parkinson's disease. Second of two parts

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Muscarinic receptor stimulation induces translocation of an alpha-synuclein oligomer from plasma membrane to a light vesicle fraction in cytoplasm

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

The ubiquitin pathway in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Dopamine transporters and neuronal injury

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Methamphetamine-induced dopamine overflow and injury to striatal dopamine terminals: attenuation by dopamine D1 or D2 antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Essential functions of synapsins I and II in synaptic vesicle regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Dopamine-releasing action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) in the neostriatum of the rat as demonstrated in vivo by the push-pull perfusion technique: dependence on sodium but not calcium io

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Characteristics of dopaminergic neurotoxicity produced by MPTP and methamphetamine

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Synoretin--A new protein belonging to the synuclein family

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

A trimeric protein complex functions as a synaptic chaperone machine.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Cloning and characterization of the cDNA encoding a novel brain-specific 14-kDa protein

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Oxidative stress and genetics in the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2803%2900036-8

7 January 2021

Protein measurement with the Folin phenol reagent

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/S0306-4522(03)00036-8

Identifiers

DOI

10.1016/S0306-4522(03)00036-8

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2 December 2017

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