Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition (Q28264605)

Impact of linker strain and flexibility in the design of a fragment-based inhibitor

Europe PubMed Central

title

Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition (English)

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author name string

Dmitry O Zharkov

series ordinal

1

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Grigory V Mechetin

series ordinal

2

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Georgy A Nevinsky

series ordinal

3

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language of work or name

English

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publication date

1 March 2010

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number of pages

10

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published in

Mutation Research

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volume

685

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page(s)

11-20

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issue

1-2

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cites work

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Electrostatic guidance of glycosyl cation migration along the reaction coordinate of uracil DNA glycosylase

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The structure of uracil-DNA glycosylase from Atlantic cod (Gadus morhua) reveals cold-adaptation features

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Domain closure and action of uracil DNA glycosylase (UDG): structures of new crystal forms containing the Escherichia coli enzyme and a comparative study of the known structures involving UDG

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The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates

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Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA

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Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase

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Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects

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Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187

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Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited

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Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase

20 March 2017

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X-ray analysis of a complex of Escherichia coli uracil DNA glycosylase (EcUDG) with a proteinaceous inhibitor. The structure elucidation of a prokaryotic UDG

20 March 2017

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A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A

20 March 2017

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Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

20 March 2017

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Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase

20 March 2017

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20 March 2017

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Structure of the gene for human uracil-DNA glycosylase and analysis of the promoter function

20 March 2017

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The structural basis of specific base-excision repair by uracil-DNA glycosylase

20 March 2017

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Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis

20 March 2017

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Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA

20 March 2017

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Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex

20 March 2017

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Molecular cloning of human uracil-DNA glycosylase, a highly conserved DNA repair enzyme

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Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage

20 March 2017

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Nontarget DNA binding shapes the dynamic landscape for enzymatic recognition of DNA damage

20 March 2017

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Uracil in DNA and its processing by different DNA glycosylases

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Uracil DNA glycosylase uses DNA hopping and short-range sliding to trap extrahelical uracils

29 September 2017

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Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.

29 September 2017

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DNA-uracil and human pathology

29 September 2017

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29 September 2017

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A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA.

29 September 2017

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Structure of a DNA glycosylase searching for lesions

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29 September 2017

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The DNA trackwalkers: principles of lesion search and recognition by DNA glycosylases

29 September 2017

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29 September 2017

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The merits of bipartite transition-state mimics for inhibition of uracil DNA glycosylase

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2 June 2018

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27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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12 December 2020

Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua)

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12 December 2020