Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair (Q27642925)

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David J Hosfield

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Seungil Han

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Junzhuan Qiu

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Biana Yelent

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Binghui Shen

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John A Tainer

Modeling of Flap Endonuclease Interactions with DNA Substrate

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publication date

9 January 2004

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language of work or name

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116

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issue

1

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page(s)

39-50

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cites work

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A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair

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Enzymes and reactions at the eukaryotic DNA replication fork

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Effect of flap modifications on human FEN1 cleavage

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Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the -clamp

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A helical arch allowing single-stranded DNA to thread through T5 5'-exonuclease

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Fluorescence resonance energy transfer and nucleic acids

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Observing the helical geometry of double-stranded DNA in solution by fluorescence resonance energy transfer

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Interactions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding

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7 January 2021

Mutations in Yeast Proliferating Cell Nuclear Antigen Define Distinct Sites for Interaction with DNA Polymerase δ and DNA Polymerase ε

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Stimulation of eukaryotic flap endonuclease-1 activities by proliferating cell nuclear antigen (PCNA) is independent of its in vitro interaction via a consensus PCNA binding region

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The acetylatable lysines of human Fen1 are important for endo- and exonuclease activities

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Two modes of FEN1 binding to PCNA regulated by DNA.

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Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA

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7 January 2021

Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair

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7 January 2021

Flap endonuclease 1: a novel tumour suppresser protein

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7 January 2021

Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1.

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7 January 2021

Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity

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The crystal structure of flap endonuclease-1 from Methanococcus jannaschii

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Evidence for involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair

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Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen

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A comparison of eubacterial and archaeal structure-specific 5'-exonucleases

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Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate

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7 January 2021

Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen.

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7 January 2021

Crystal structure of Thermus aquaticus DNA polymerase

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Human flap endonuclease-1: conformational change upon binding to the flap DNA substrate and location of the Mg2+ binding site

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Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

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Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

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Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression

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Crystal structure of NAD+-dependent DNA ligase: modular architecture and functional implications

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Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by Proliferating Cell Nuclear Antigen

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The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair

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Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1.

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7 January 2021

Molecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshii

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7 January 2021

Crystal structure of an archaeal DNA sliding clamp: proliferating cell nuclear antigen from Pyrococcus furiosus

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7 January 2021

Physical interaction between proliferating cell nuclear antigen and replication factor C from Pyrococcus furiosus

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7 January 2021

Molecular mechanism of PCNA-dependent base excision repair

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7 January 2021

Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins

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7 January 2021

Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination

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7 January 2021

The kinetics of oligonucleotide replacements

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Crystal Structures of Human DNA Polymerase β Complexed with Gapped and Nicked DNA: Evidence for an Induced Fit Mechanism,

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7 January 2021

Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex

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7 January 2021

Flap endonuclease homologs in archaebacteria exist as independent proteins.

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7 January 2021

The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.

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7 January 2021

Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1

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7 January 2021

PCNA binding through a conserved motif

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7 January 2021

Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage

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7 January 2021

Clamp loading, unloading and intrinsic stability of the PCNA, beta and gp45 sliding clamps of human, E. coli and T4 replicases

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7 January 2021