Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression (Q34098053)

31 July 2017

title

Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression (English)

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31 July 2017

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Melanie Kucherlapati

1

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31 July 2017

Kan Yang

2

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31 July 2017

Mari Kuraguchi

3

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31 July 2017

Jie Zhao

4

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31 July 2017

Maria Lia

5

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31 July 2017

Joerg Heyer

6

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31 July 2017

Michael F Kane

7

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31 July 2017

Kunhua Fan

8

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31 July 2017

Robert Russell

9

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31 July 2017

Anthony M C Brown

10

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31 July 2017

Burkhard Kneitz

11

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31 July 2017

Winfried Edelmann

12

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31 July 2017

Richard D Kolodner

13

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31 July 2017

Martin Lipkin

14

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31 July 2017

Raju Kucherlapati

15

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31 July 2017

publication date

15 July 2002

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Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

language of work or name

English

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published in

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31 July 2017

volume

99

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31 July 2017

issue

15

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31 July 2017

page(s)

9924-9929

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Overlapping Functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 Nucleases in DNA Metabolism

31 July 2017

cites work

1 reference

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The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis

5 July 2018

1 reference

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The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Deficient DNA mismatch repair: a common etiologic factor for colon cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

The mammalian FEN-1 locus: structure and conserved sequence features

5 July 2018

1 reference

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DNA mismatch repair and cancer

5 July 2018

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The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers

5 July 2018

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Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers

5 July 2018

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The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression

5 July 2018

1 reference

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Conversion of diploidy to haploidy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Germ-line msh6 mutations in colorectal cancer families

5 July 2018

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Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations.

5 July 2018

1 reference

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Familial endometrial cancer in female carriers of MSH6 germline mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Eukaryotic DNA mismatch repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer

5 July 2018

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Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Destabilization of Yeast Micro- and Minisatellite DNA Sequences by Mutations Affecting a Nuclease Involved in Okazaki Fragment Processing (rad27) and DNA Polymerase δ (pol3-t)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression

5 July 2018

1 reference

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Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA.

5 July 2018

1 reference

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Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

5 July 2018

1 reference

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The characterization of a mammalian DNA structure-specific endonuclease

5 July 2018

1 reference

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A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

DNA structural elements required for FEN-1 binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Microsatellite instability in inherited and sporadic neoplasms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by Proliferating Cell Nuclear Antigen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Mutations in RAD27 define a potential link between G1 cyclins and DNA replication

5 July 2018

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Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.

5 July 2018

1 reference

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Localization of the gene for familial adenomatous polyposis on chromosome 5.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

Identification of FAP locus genes from chromosome 5q21

5 July 2018

1 reference

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Identification and characterization of the familial adenomatous polyposis coli gene

5 July 2018

1 reference

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A 5' to 3' exonuclease functionally interacts with calf DNA polymerase epsilon

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

The gene for familial polyposis coli maps to the long arm of chromosome 5.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.152321699

Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.152321699

Involvement of flap endonuclease 1 in base excision DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.152321699

Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.152321699

Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126601

The role of hPMS1 and hPMS2 in predisposing to colorectal cancer

28 October 2018

1 reference

12 December 2020

MSH2 in contrast to MLH1 and MSH6 is frequently inactivated by exonic and promoter rearrangements in hereditary nonpolyposis colorectal cancer

1 reference

12 December 2020

Excision of Pyrimidine Dimers from Ultraviolet-Irradiated DNA by Exonucleases from Mammalian Cells

1 reference

12 December 2020

Protein-primed replication of plasmids containing the terminus of the adenovirus genome. II. Purification and characterization of a host protein required for the replication of DNA templates devoid of the terminal protein

1 reference

12 December 2020

Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients

1 reference

12 December 2020

Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency

1 reference

12 December 2020

Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes

1 reference

12 December 2020

A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair

1 reference

12 December 2020

A mouse model of human familial adenomatous polyposis

1 reference

12 December 2020

Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer

1 reference

12 December 2020

MSH2 genomic deletions are a frequent cause of HNPCC

1 reference

12 December 2020

Suspected hereditary nonpolyposis colorectal cancer

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.152321699

1 reference

31 July 2017

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31 July 2017

1 reference