Flap endonuclease 1: a novel tumour suppresser protein (Q35183869)

7 August 2017

title

Flap endonuclease 1: a novel tumour suppresser protein (English)

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7 August 2017

Ghislaine Henneke

1

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7 August 2017

Erica Friedrich-Heineken

series ordinal

2

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7 August 2017

Ulrich Hübscher

series ordinal

3

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7 August 2017

publication date

1 July 2003

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7 August 2017

number of pages

7

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Trends in Biochemical Sciences

inferred from page(s)

published in

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7 August 2017

volume

28

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7 August 2017

issue

7

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7 August 2017

page(s)

384-390

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publication type of scholarly work

7 August 2017

review article

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The characterization of a mammalian DNA structure-specific endonuclease

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Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

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7 January 2021

The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair

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7 January 2021

A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair

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7 January 2021

A comparison of eubacterial and archaeal structure-specific 5'-exonucleases

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7 January 2021

Cleavage of substrates with mismatched nucleotides by Flap endonuclease-1. Implications for mammalian Okazaki fragment processing

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7 January 2021

A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events

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7 January 2021

Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression

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7 January 2021

Cancer biology. A matter of dosage

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7 January 2021

The crystal structure of flap endonuclease-1 from Methanococcus jannaschii

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7 January 2021

Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity

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7 January 2021

Flexible loops and helical arches

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7 January 2021

Flap endonuclease homologs in archaebacteria exist as independent proteins.

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7 January 2021

Distinct roles of two Mg2+ binding sites in regulation of murine flap endonuclease-1 activities

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7 January 2021

The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.

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7 January 2021

Effect of flap modifications on human FEN1 cleavage

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7 January 2021

Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1.

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7 January 2021

In eukaryotic flap endonuclease 1, the C terminus is essential for substrate binding

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7 January 2021

Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300

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7 January 2021

Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation

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7 January 2021

Conditional lethality of null mutations in RTH1 that encodes the yeast counterpart of a mammalian 5'- to 3'-exonuclease required for lagging strand DNA synthesis in reconstituted systems

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7 January 2021

RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes

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7 January 2021

A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function

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7 January 2021

Two modes of FEN1 binding to PCNA regulated by DNA.

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7 January 2021

Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansion

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7 January 2021

Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate

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7 January 2021

The acetylatable lysines of human Fen1 are important for endo- and exonuclease activities

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7 January 2021

Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage

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7 January 2021

The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability

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7 January 2021

Okazaki fragment maturation in yeast. I. Distribution of functions between FEN1 AND DNA2.

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7 January 2021

Okazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3'-5'-exonuclease activities of Pol delta in the creation of a ligatable nick

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7 January 2021

Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1

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7 January 2021

Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen

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7 January 2021

Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair

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7 January 2021

Mutations in Yeast Proliferating Cell Nuclear Antigen Define Distinct Sites for Interaction with DNA Polymerase δ and DNA Polymerase ε

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7 January 2021

Biochemical characterization of the WRN-FEN-1 functional interaction

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7 January 2021

Genome maintenance mechanisms for preventing cancer

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7 January 2021

Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene

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7 January 2021

Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon

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7 January 2021

FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.

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7 January 2021

Flap endonuclease 1 efficiently cleaves base excision repair and DNA replication intermediates assembled into nucleosomes

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7 January 2021

Repair of UV damage in the fission yeast Schizosaccharomyces pombe

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7 January 2021

Characterization of the alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe.

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7 January 2021

Processing of UV damage in vitro by FEN-1 proteins as part of an alternative DNA excision repair pathway

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7 January 2021

In vitro reconstitution of the Schizosaccharomyces pombe alternative excision repair pathway

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7 January 2021

Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants

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7 January 2021

Novel function of Rad27 (FEN-1) in restricting short-sequence recombination

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7 January 2021

Destabilization of Yeast Micro- and Minisatellite DNA Sequences by Mutations Affecting a Nuclease Involved in Okazaki Fragment Processing (rad27) and DNA Polymerase δ (pol3-t)

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7 January 2021

Expansion and Length-Dependent Fragility of CTG Repeats in Yeast

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7 January 2021

Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900138-5

7 January 2021

Mutations in RAD27 define a potential link between G1 cyclins and DNA replication

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900138-5

7 January 2021

Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900138-5

7 January 2021

Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2

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7 January 2021

Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900138-5

7 January 2021

DNA ligase I competes with FEN1 to expand repetitive DNA sequences in vitro

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900138-5

7 January 2021

Vertebrate cells lacking FEN-1 endonuclease are viable but hypersensitive to methylating agents and H2O2.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900138-5

7 January 2021

Stimulation of RTH1 nuclease of the yeast Saccharomyces cerevisiae by replication protein A.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900138-5

7 January 2021

p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900138-5

7 January 2021

Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900138-5

7 January 2021

Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination

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7 January 2021

Stimulation of eukaryotic flap endonuclease-1 activities by proliferating cell nuclear antigen (PCNA) is independent of its in vitro interaction via a consensus PCNA binding region

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7 January 2021

10.1016/S0968-0004(03)00138-5

Identifiers

DOI

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7 August 2017

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