Roles and mechanisms of cellular senescence in regulation of tissue homeostasis (Q26999018)

language of work or name

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May 2013

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104

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issue

5

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page(s)

525-30

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The biology of aging: 1985-2010 and beyond

cites work

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The common biology of cancer and ageing

21 January 2018

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

21 January 2018

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Regulation of growth arrest in senescence: telomere damage is not the end of the story

21 January 2018

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Cancer: crime and punishment.

21 January 2018

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Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence

21 January 2018

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Senescence in tumours: evidence from mice and humans

21 January 2018

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The essence of senescence

21 January 2018

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Four faces of cellular senescence.

21 January 2018

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

21 January 2018

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Telomere dysfunction and tumour suppression: the senescence connection

21 January 2018

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Telomeres shorten during ageing of human fibroblasts

21 January 2018

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Shelterin: the protein complex that shapes and safeguards human telomeres

21 January 2018

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Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

21 January 2018

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Cellular senescence: mitotic clock or culture shock?

21 January 2018

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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Putting the stress on senescence

21 January 2018

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Living on a break: cellular senescence as a DNA-damage response

21 January 2018

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Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

21 January 2018

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Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

21 January 2018

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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

21 January 2018

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Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

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Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.

21 January 2018

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The retinoblastoma protein and the regulation of cell cycling

21 January 2018

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The retinoblastoma tumour suppressor in development and cancer

21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

21 January 2018

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

21 January 2018

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

21 January 2018

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Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes

21 January 2018

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Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)

21 January 2018

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Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo

21 January 2018

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

21 January 2018

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

21 January 2018

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Reinitiation of cellular DNA synthesis in BrdU-selected nondividing senescent WI-38 cells by simian virus 40 infection

21 January 2018

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Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

21 January 2018

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Feedback between p21 and reactive oxygen production is necessary for cell senescence

21 January 2018

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Oxidant signals and oxidative stress

21 January 2018

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LATS tumor suppressor: a new governor of cellular homeostasis

21 January 2018

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Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

21 January 2018

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Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

21 January 2018

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Persistent telomere damage induces bypass of mitosis and tetraploidy

21 January 2018

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Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells

21 January 2018

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Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells.

21 January 2018

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Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.

21 January 2018

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Ink4a/Arf expression is a biomarker of aging

21 January 2018

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Chemokine signaling via the CXCR2 receptor reinforces senescence

21 January 2018

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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

21 January 2018

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

21 January 2018

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Senescence-messaging secretome: SMS-ing cellular stress

21 January 2018

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

21 January 2018

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Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)

21 January 2018

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Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

21 January 2018

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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

21 January 2018

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Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.

21 January 2018

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Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression

21 January 2018

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The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

21 January 2018

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Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations

21 January 2018

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Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

21 January 2018

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p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

21 January 2018

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DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells

21 January 2018

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The diverse functions of histone lysine methylation

21 January 2018

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H3K9 methyltransferase G9a and the related molecule GLP.

21 January 2018

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Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

21 January 2018

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G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.

21 January 2018

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Restoration of p53 function leads to tumour regression in vivo

21 January 2018

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

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Senescence of activated stellate cells limits liver fibrosis

21 January 2018

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A role for both RB and p53 in the regulation of human cellular senescence

21 January 2018

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12 December 2020

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

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12 December 2020

Causes and consequences of aneuploidy in cancer.

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12 December 2020

p16 INK4a can initiate an autonomous senescence program

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12 December 2020

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12 December 2020

Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer

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12 December 2020

Serial propagation of 3 strains of rabbit fibroblasts; their susceptibility to infection with vaccinia virus.

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12 December 2020