The retinoblastoma tumour suppressor in development and cancer (Q34161991)

31 July 2017

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title

The retinoblastoma tumour suppressor in development and cancer (English)

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31 July 2017

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Marie Classon

1

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31 July 2017

Ed Harlow

series ordinal

2

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31 July 2017

language of work or name

English

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publication date

1 December 2002

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31 July 2017

Nature Reviews Cancer

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31 July 2017

2

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31 July 2017

910-917

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31 July 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrc950

31 July 2017

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cites work

Some early studies of human chromosomes, 1879-1955

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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

31 March 2020

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Human retinoblastoma susceptibility gene: cloning, identification, and sequence.

31 March 2020

1 reference

Structural evidence for the authenticity of the human retinoblastoma gene

31 March 2020

1 reference

31 March 2020

Tumor suppressor genes

1 reference

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

31 March 2020

1 reference

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

31 March 2020

1 reference

Identification of a growth suppression domain within the retinoblastoma gene product

31 March 2020

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Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells

31 March 2020

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The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

31 March 2020

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Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts

31 March 2020

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pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

31 March 2020

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Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control

31 March 2020

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A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

31 March 2020

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Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis

31 March 2020

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E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

31 March 2020

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The regulation of E2F by pRB-family proteins

31 March 2020

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Sibling rivalry in the E2F family

31 March 2020

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Transcriptional inhibition by the retinoblastoma protein

31 March 2020

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Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

31 March 2020

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Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

31 March 2020

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Retinoblastoma protein switches the E2F site from positive to negative element

31 March 2020

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Mechanism of active transcriptional repression by the retinoblastoma protein

31 March 2020

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E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

31 March 2020

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Direct transcriptional repression by pRB and its reversal by specific cyclins

31 March 2020

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The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter

31 March 2020

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Chromatin remodeling and Rb activity

31 March 2020

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Retinoblastoma protein meets chromatin

31 March 2020

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The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

31 March 2020

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Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle

31 March 2020

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31 March 2020

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Nuclear organization of DNA replication in primary mammalian cells.

31 March 2020

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ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP.

31 March 2020

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DNA replication control through interaction of E2F-RB and the origin recognition complex

31 March 2020

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The retinoblastoma gene family in differentiation and development.

31 March 2020

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The role of p53 and pRB in apoptosis and cancer

31 March 2020

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p53 and E2F-1 cooperate to mediate apoptosis

31 March 2020

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Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

31 March 2020

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Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

31 March 2020

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Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

31 March 2020

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Apaf-1 is a transcriptional target for E2F and p53

31 March 2020

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E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

31 March 2020

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Retinoblastoma protein partners

31 March 2020

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The retinoblastoma gene family: cousins with overlapping interests.

31 March 2020

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p107 and p130: versatile proteins with interesting pockets

31 March 2020

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Growth suppression by members of the retinoblastoma protein family

31 March 2020

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Specific regulation of E2F family members by cyclin-dependent kinases

31 March 2020

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p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

31 March 2020

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Retinoblastoma gene promoter directs transgene expression exclusively to the nervous system

31 March 2020

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pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.

31 March 2020

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Effects of an Rb mutation in the mouse

31 March 2020

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

31 March 2020

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p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

31 March 2020

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Tumor suppressor gene mutations in mice

31 March 2020

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TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein

31 March 2020

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pRB plays an essential role in cell cycle arrest induced by DNA damage

31 March 2020

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Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

31 March 2020

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Opposing roles of pRB and p107 in adipocyte differentiation

31 March 2020

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Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs

31 March 2020

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Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle

31 March 2020

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pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation

31 March 2020

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Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

31 March 2020

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Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis.

31 March 2020

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Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6

31 March 2020

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Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

31 March 2020

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Distinct roles for E2F proteins in cell growth control and apoptosis

31 March 2020

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E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

31 March 2020

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Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

31 March 2020

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Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice

31 March 2020

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The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein

31 March 2020

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Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

31 March 2020

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Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system

31 March 2020

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Developmental defects and tumor predisposition in Rb mutant mice

31 March 2020

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Cell-nonautonomous function of the retinoblastoma tumour suppressor protein: new interpretations of old phenotypes

31 March 2020

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Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development

31 March 2020

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Shared role of the pRB-related p130 and p107 proteins in limb development

31 March 2020

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Targeted disruption of p107: functional overlap between p107 and Rb

31 March 2020

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Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene.

31 March 2020

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p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB.

31 March 2020

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Target gene specificity of E2F and pocket protein family members in living cells

31 March 2020

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Requirements for cell cycle arrest by p16INK4a

31 March 2020

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E2Fs regulate adipocyte differentiation

31 March 2020

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p107 is a suppressor of retinoblastoma development in pRb-deficient mice

31 March 2020

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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

31 March 2020

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Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

31 March 2020

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Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells

31 March 2020

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Cooperative tumorigenic effects of germline mutations in Rb and p53

31 March 2020

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Retinoblastoma in transgenic mice

31 March 2020

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Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen

31 March 2020

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Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

31 March 2020

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Tumor induction and tissue atrophy in mice lacking E2F-1

31 March 2020

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E2F-1 functions in mice to promote apoptosis and suppress proliferation

31 March 2020

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E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

31 March 2020

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Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

31 March 2020

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Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma

31 March 2020

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lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.

31 March 2020

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dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development

31 March 2020

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C. elegans class B synthetic multivulva genes act in G(1) regulation

31 March 2020

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The transcription factor E2F is required for S phase during Drosophila embryogenesis

31 March 2020

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RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila

31 March 2020

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Functional antagonism between E2F family members

31 March 2020

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Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2

31 March 2020

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Coordination of growth and cell division in the Drosophila wing.

31 March 2020

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Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

31 March 2020

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Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins

31 March 2020

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Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins

31 March 2020

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Role of the LXCXE binding site in Rb function

31 March 2020

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Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function

31 March 2020

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RB-dependent S-phase response to DNA damage

31 March 2020

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Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.

31 March 2020

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Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

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inferred from DOI database lookup

7 January 2021

based on heuristic

Acetylation control of the retinoblastoma tumour-suppressor protein

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC950

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Dimensions Publication ID

31 July 2017

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