Senescence in tumours: evidence from mice and humans (Q36903843)

17 August 2017

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title

Senescence in tumours: evidence from mice and humans (English)

1 reference

17 August 2017

Manuel Collado

1

1 reference

PMCID

3672965

17 August 2017

Manuel Serrano

series ordinal

2

1 reference

PMCID

3672965

17 August 2017

language of work or name

English

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publication date

1 January 2010

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17 August 2017

Nature Reviews Cancer

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17 August 2017

10

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17 August 2017

51-57

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17 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrc2772

17 August 2017

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Chemokine signaling via the CXCR2 receptor reinforces senescence

29 September 2017

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29 September 2017

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A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition

29 September 2017

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29 September 2017

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Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo

29 September 2017

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Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

29 September 2017

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29 September 2017

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Short telomeres limit tumor progression in vivo by inducing senescence

29 September 2017

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Hyperactive Ras in developmental disorders and cancer

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Restoration of p53 function leads to tumour regression in vivo

29 September 2017

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

29 September 2017

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29 September 2017

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29 September 2017

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

29 September 2017

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29 September 2017

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Intrinsic tumour suppression

29 September 2017

1 reference

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The serial cultivation of human diploid cell strains

29 September 2017

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Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

29 September 2017

1 reference

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

29 September 2017

1 reference

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Tumor cell senescence in cancer treatment

29 September 2017

1 reference

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The biology of neoadjuvant chemotherapy for breast cancer

29 September 2017

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Signaling networks that link cell proliferation and cell fate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Senescence of human fibroblasts induced by oncogenic Raf.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Tumour biology: senescence in premalignant tumours

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

A negative feedback signaling network underlies oncogene-induced senescence

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

The power and the promise of oncogene-induced senescence markers.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Oncogene-induced senescence as an initial barrier in lymphoma development

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672965

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNRC2772

31 March 2020

Identifiers

DOI

10.1038/NRC2772

1 reference

17 August 2017

1 reference

17 August 2017

1 reference

PMCID

3672965