Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein (Q24630479)

1

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G Middleton

2

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J Adu

3

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N N Ninkina

4

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L B Drobot

5

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V Filonenko

6

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G Matsuka

7

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A M Davies

8

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M Waterfield

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V L Buchman

Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl

10

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language of work or name

English

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publication date

1 August 2000

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published in

The EMBO Journal

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volume

19

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issue

15

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page(s)

4015-25

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cites work

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CMS: an adapter molecule involved in cytoskeletal rearrangements

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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

7 April 2017

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

7 April 2017

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

7 April 2017

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The scanning model for translation: an update

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Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system

7 April 2017

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Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes

7 April 2017

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Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p

7 April 2017

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Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains

7 April 2017

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Signaling by distinct classes of phosphoinositide 3-kinases

7 April 2017

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Signalling through phosphoinositide 3-kinases: the lipids take centre stage

7 April 2017

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

7 April 2017

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A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts

7 April 2017

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FYVE fingers bind PtdIns(3)P

7 April 2017

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Akt signaling: linking membrane events to life and death decisions

7 April 2017

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Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger

7 April 2017

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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

7 April 2017

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Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase

7 April 2017

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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

7 April 2017

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p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons

7 April 2017

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Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

7 April 2017

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Persyn, a member of the synuclein family, has a distinct pattern of expression in the developing nervous system

7 April 2017

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Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase

7 April 2017

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Differential splicing creates a diversity of transcripts from a neurospecific developmentally regulated gene encoding a protein with new zinc-finger motifs

7 April 2017

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

7 April 2017

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7 April 2017

Phosphoinositide kinases

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The GTPase dynamin binds to and is activated by a subset of SH3 domains

7 April 2017

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7 April 2017

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Phosphoinositide binding domains: embracing 3-phosphate

21 January 2018

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Intermolecular interactions of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase.

27 September 2017

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

27 September 2017

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The role of phosphoinositide 3-kinase lipid products in cell function

27 September 2017

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The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells

27 September 2017

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Ras signalling and apoptosis

27 September 2017

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Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells

27 September 2017

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A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

27 September 2017

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Phosphoinositide 3-kinases: a conserved family of signal transducers

27 September 2017

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Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase.

27 September 2017

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Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.

27 September 2017

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Expression and function of TrkB variants in developing sensory neurons.

27 September 2017

1 reference

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Identification of amino acid residues required for a specific interaction between Src-tyrosine kinase and proline-rich region of phosphatidylinositol-3' kinase

27 September 2017

1 reference

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Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase

27 September 2017

1 reference

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Recognition and specificity in protein tyrosine kinase-mediated signalling

27 September 2017

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p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells

27 September 2017

1 reference

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A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo

27 September 2017

1 reference

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Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

27 September 2017

1 reference

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PI 3-kinase: structural and functional analysis of intersubunit interactions

27 September 2017

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Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.

27 September 2017

1 reference

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Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits

27 September 2017

1 reference

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The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

27 September 2017

1 reference

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The v-Src SH3 domain binds phosphatidylinositol 3'-kinase

27 September 2017

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Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.

27 September 2017

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Signal transduction by the neurotrophin receptors

27 September 2017

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Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells.

27 September 2017

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

30 May 2018

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A functional PtdIns(3)P-binding motif.

30 May 2018

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Mechanisms and consequences of activation of protein kinase B/Akt

30 May 2018

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30 May 2018

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Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons

30 May 2018

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

30 May 2018

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In sympathetic but not sensory neurones, phosphoinositide-3 kinase is important for NGF-dependent survival and the retrograde transport of 125I-betaNGF.

30 May 2018

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Using structure to define the function of phosphoinositide 3-kinase family members

30 May 2018

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[Cloning of genes, differentially expressed in the cerebellum during postnatal rat development]

30 May 2018

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Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways

30 May 2018

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The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis.

30 May 2018

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Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase

30 May 2018

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Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns

30 May 2018

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Differential mRNA expression and subcellular locations of PI3-kinase isoforms in sympathetic and sensory neurons.

30 May 2018

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Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.

21 January 2018

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

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21 January 2018

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Phosphatidylinositol 3-Phosphate Recognition by the FYVE Domain

21 January 2018

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The role of PI 3-kinase in insulin action

21 January 2018

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Congenital nephrotic syndrome in mice lacking CD2-associated protein

21 January 2018

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Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes

28 November 2018

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Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase

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Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells

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Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development

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