Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. (Q52177288)

26 April 2018

title

Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. (English)

1 reference

26 April 2018

author name string

Klesse LJ

1

1 reference

26 April 2018

Meyers KA

2

1 reference

26 April 2018

Marshall CJ

3

1 reference

26 April 2018

Parada LF

4

1 reference

26 April 2018

language of work or name

English

0 references

publication date

1 March 1999

1 reference

26 April 2018

published in

Oncogene

1 reference

26 April 2018

volume

18

1 reference

26 April 2018

issue

12

1 reference

26 April 2018

page(s)

2055-2068

1 reference

26 April 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1202524

exact match

0 references

cites work

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Mutational activation of c-raf-1 and definition of the minimal transforming sequence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Akt signaling: linking membrane events to life and death decisions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Nerve growth factor mediates signal transduction through trk homodimer receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Signal transduction by the neurotrophin receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Regulators of cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Bcl-2 gene family in the nervous system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Active p21Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Errors of homeostasis and deregulated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Intracellular signaling pathways activated by neurotrophic factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Dorsal root ganglion neurons require functional neurotrophin receptors for survival during development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Mechanism of activation of a human oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Nutritional support of brain-injured patients. Brain Trauma Foundation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202524

1 reference

26 April 2018

PubMed ID

10321730

1 reference

26 April 2018