The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation (Q24296660)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12614355%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation (English)

1 reference

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LCK proto-oncogene, Src family tyrosine kinase

1 November 2019

main subject

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positive regulation of T cell receptor signaling pathway

GOA release 2020-03-11

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GOA release 2020-03-11

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4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12614355%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Rose Zamoyska

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12614355%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Michiel Albertus Basson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12614355%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Benedict Seddon

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12614355%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

3

Andrew Filby

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12614355%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

author name string

Matthew Lovatt

5

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1 November 2019

publication date

1 February 2003

1 reference

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1 November 2019

language of work or name

English

0 references

published in

Immunological Reviews

1 reference

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1 November 2019

volume

191

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12614355%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

page(s)

107-118

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publication type of scholarly work

1 November 2019

review article

1 reference

Population biology of lymphocytes: the flight for survival

cites work

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00015.X

Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes

20 April 2017

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00015.X

Profound block in thymocyte development in mice lacking p56lck

20 April 2017

1 reference

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Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

20 April 2017

1 reference

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

20 April 2017

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Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

20 April 2017

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00015.X

Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro

20 April 2017

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00015.X

Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling

20 April 2017

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00015.X

Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

20 April 2017

1 reference

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Molecular Interaction between the Fyn-associated Protein SKAP55 and the SLP-76-associated Phosphoprotein SLAP-130

20 April 2017

1 reference

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A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

20 April 2017

1 reference

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Cellular functions regulated by Src family kinases

20 April 2017

1 reference

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Peripheral T cell survival

20 April 2017

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

The cysteine residues in the cytoplasmic tail of CD8 α are required for its coreceptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Positive and negative selection of thymocytes depends on Lck interaction with the CD4 and CD8 coreceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Proximal protein tyrosine kinases in immunoreceptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Positive and negative regulation of leukocyte activation by protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

CD3 Ligation on Immature Thymocytes Generates Antagonist-like Signals Appropriate for CD8 Lineage Commitment, Independently of T Cell Receptor Specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Long-Term Survival But Impaired Homeostatic Proliferation of Naive T Cells in the Absence of p56lck

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

TCR signals mediated by Src family kinases are essential for the survival of naive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

TCR and IL-7 receptor signals can operate independently or synergize to promote lymphopenia-induced expansion of naive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Lck plays a critical role in Ca2+ mobilization and CD28 costimulation in mature primary T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Differential T-cell antigen receptor signaling mediated by the Src family kinases Lck and Fyn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Src family tyrosine kinases and growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Functional LCK Is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Differences in binding of PI 3-kinase to the src-homology domains 2 and 3 of p56 lck and p59 fyn tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Selective activation of T cell kinase p56lck by Herpesvirus saimiri protein tip.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

T-cell development and the CD4-CD8 lineage decision

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Maintaining the norm: T-cell homeostasis

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Multiple features of the p59fyn src homology 4 domain define a motif for immune-receptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localization

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Helper T-cell development in the absence of CD4-p56 Ick association

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

A crystal milestone: the structure of regulated Src.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Thymic tumorigenesis induced by overexpression of p56lck

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Protein tyrosine kinase p56 lck controls allelic exclusion of T-cell receptor β-chain genes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Fyn can partially substitute for Lck in T lymphocyte development

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Molecular requirements for lineage commitment in the thymus--antibody-mediated receptor engagements reveal a central role for lck in lineage decisions

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Lck activity controls CD4/CD8 T cell lineage commitment.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Survival and homeostatic proliferation of naive peripheral CD4+ T cells in the absence of self peptide:MHC complexes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Differential Survival of Naive CD4 and CD8 T Cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and pp32, a possible common substrate

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

p56lck interacts via its src homology 2 domain with the ZAP-70 kinase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Ras GTPase-activating protein: a substrate and a potential binding protein of the protein-tyrosine kinase p56lck

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00015.X

7 January 2021

10.1034/J.1600-065X.2003.00015.X

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12614355%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017