Molecular Interaction between the Fyn-associated Protein SKAP55 and the SLP-76-associated Phosphoprotein SLAP-130 (Q28283375)

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signal transducing adaptor protein

10 January 2025

main subject

molecular interaction

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based on heuristic

inferred from title

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author name string

A. Marie-Cardine

1

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L. R. Hendricks-Taylor

2

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N. J. Boerth

3

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H. Zhao

4

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B. Schraven

5

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G. A. Koretzky

6

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http://www.jbc.org/content/273/40/25789.full.pdf

10 January 2025

publication date

2 October 1998

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language of work or name

English

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work available at URL

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https://api.elsevier.com/content/article/PII:S0021925819598891?httpAccept=text/xml

10 January 2025

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https://api.elsevier.com/content/article/PII:S0021925819598891?httpAccept=text/plain

10 January 2025

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https://syndication.highwire.org/content/doi/10.1074/jbc.273.40.25789

10 January 2025

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Journal of Biological Chemistry

10 January 2025

published in

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volume

273

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issue

40

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page(s)

25789-95

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cites work

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein

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Both T cell receptor (TcR)-CD3 complex and CD2 increase the tyrosine kinase activity of p56lck. CD2 can mediate TcR-CD3-independent and CD45-dependent activation of p56lck

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Signal transduction by lymphocyte antigen receptors

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Profound block in thymocyte development in mice lacking p56lck

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Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

21 January 2018

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alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

21 January 2018

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Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor

21 January 2018

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Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production

21 January 2018

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Engagement of the TcR/CD3 complex stimulates p59fyn(T) activity: detection of associated proteins at 72 and 120-130 kD.

21 January 2018

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p59fyn tyrosine kinase regulates p56lck tyrosine kinase activity and early TCR-mediated signaling.

21 January 2018

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Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).

21 January 2018

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Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes

21 January 2018

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Molecular analysis of the fyn-complex: cloning of SKAP55 and SLAP-130, two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor-mediated signaling

21 January 2018

1 reference

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Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases

21 January 2018

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Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

21 January 2018

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pEF-BOS, a powerful mammalian expression vector

21 January 2018

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pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

21 January 2018

1 reference

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Fyn can partially substitute for Lck in T lymphocyte development

21 January 2018

1 reference

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p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain

21 January 2018

13

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