Jump to content

LCK proto-oncogene, Src family tyrosine kinase (Q9020944)

From Wikidata
mammalian protein found in Homo sapiens
  • T-lymphocyte specific protein tyrosine kinase p56lck
  • proto-oncogene tyrosine-protein kinase LCK
  • LSK
  • p56-LCK
  • lymphocyte cell-specific protein-tyrosine kinase
  • leukocyte C-terminal Src kinase
  • Protein YT16
  • p56(LSTRA) protein-tyrosine kinase
  • tyrosine-protein kinase Lck
  • Proto-oncogene Lck
  • LCK
  • t cell-specific protein-tyrosine kinase
  • Tyrosine-protein kinase Lck
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
edit
Language Label Description Also known as
default for all languages
No label defined
    English
    LCK proto-oncogene, Src family tyrosine kinase
    mammalian protein found in Homo sapiens
    • T-lymphocyte specific protein tyrosine kinase p56lck
    • proto-oncogene tyrosine-protein kinase LCK
    • LSK
    • p56-LCK
    • lymphocyte cell-specific protein-tyrosine kinase
    • leukocyte C-terminal Src kinase
    • Protein YT16
    • p56(LSTRA) protein-tyrosine kinase
    • tyrosine-protein kinase Lck
    • Proto-oncogene Lck
    • LCK
    • t cell-specific protein-tyrosine kinase
    • Tyrosine-protein kinase Lck
    • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    51 references
    retrieved
    8 April 2019
    stated in
    BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappa B, and serine and tyrosine phosphorylation of Ikappa B-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PKD2 interacts with Lck and regulates NFAT activity in T cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Unc119, a novel activator of Lck/Fyn, is essential for T cell activation
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human Homologue of the Drosophila Discs Large Tumor Suppressor Binds to p56 Tyrosine Kinase and Shaker Type Kv1.3 Potassium Channel in T Lymphocytes
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytes
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular basis for regulation of Src by the docking protein p130Cas
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Characterization of Lck-binding elements in the herpesviral regulatory Tip protein
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proline to glycine mutation in the Lck SH3-domain affects conformational sampling and increases ligand binding affinity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of substrates of human protein-tyrosine phosphatase PTPN22
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Large-scale structural analysis of the classical human protein tyrosine phosphatome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of Bcl-3 through interaction with the Lck tyrosine kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Distinct interactions between ubiquitin and the SH3 domains involved in immune signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Tyrosine phosphorylation of the Tio oncoprotein is essential for transformation of primary human T cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The C terminus of T cell-specific adapter protein (TSAd) is necessary for TSAd-mediated inhibition of Lck activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IPI
    protein tyrosine kinase activity
    determination method or standard
    EXP
    IDA
    IEA
    IMP
    ISS
    TAS
    10 references
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
    determination method or standard
    ISS
    retrieved
    1 January 2018
    stated in
    Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
    determination method or standard
    EXP
    retrieved
    1 January 2018
    stated in
    Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
    determination method or standard
    EXP
    retrieved
    1 January 2018
    stated in
    Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
    determination method or standard
    EXP
    retrieved
    1 January 2018
    stated in
    Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
    determination method or standard
    EXP
    protein tyrosine kinase activity
    determination method or standard
    EXP
    IDA
    IEA
    IMP
    TAS
    9 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein
    GOA
    curator
    UniProt
    UniProt protein ID
    P06239
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    EXP
    retrieved
    8 April 2019
    stated in
    Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    EXP
    retrieved
    8 April 2019
    stated in
    Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    EXP
    retrieved
    8 April 2019
    stated in
    Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
    determination method or standard
    EXP
    cell component
    biological process
    Gene Atlas image
    PBB GE LCK 204891 s at fs.png
    732 × 530; 10 KB
    0 references

    Identifiers

    MeSH descriptor ID
    D019860
    subject named as
    Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
    0 references
    PDB structure ID
     
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    edit
                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q9020944&oldid=2383276245"