CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism (Q60930323)

2

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Jing Xun

3

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Wei Zhou

4

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Jun Li

5

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Juan Wang

6

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Chen Liu

7

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Xiru Li

8

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Wenzhi Shen

9

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Huan Qiao

10

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Dwayne G Stupack

11

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Na Luo

Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression

12

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language of work or name

English

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publication date

2018

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published in

Theranostics

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volume

8

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issue

22

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page(s)

6248-6262

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cites work

1 reference

12 December 2020

The expression of the CD44 variant exon 6 is associated with lymph node metastasis in non-small cell lung cancer

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12 December 2020

Expression of CD44 variants and its association with survival in pancreatic cancer.

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12 December 2020

A switch in the kinase domain of rat testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

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12 December 2020

Expression of CD44 variants and prognosis in oesophageal squamous cell carcinoma

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12 December 2020

CD44V6 in gastric carcinoma: a marker of tumor progression

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12 December 2020

Stem cells, cancer, and cancer stem cells

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12 December 2020

Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

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12 December 2020

A requirement for the CD44 cytoplasmic domain for hyaluronan binding, pericellular matrix assembly, and receptor-mediated endocytosis in COS-7 cells

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12 December 2020

Hypoxia--a key regulatory factor in tumour growth

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12 December 2020

CD44: from adhesion molecules to signalling regulators

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12 December 2020

Prospective identification of tumorigenic breast cancer cells

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12 December 2020

CD44 variant 6 in endometrioid carcinoma of the uterus: its expression in the adenocarcinoma component is an independent prognostic marker

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12 December 2020

Prognostic significance of CD44v5 expression in human thymic epithelial neoplasms

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12 December 2020

Exploiting tumour hypoxia in cancer treatment

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12 December 2020

Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors.

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12 December 2020

Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines.

1 reference

12 December 2020

Gamma-secretase-dependent proteolysis of CD44 promotes neoplastic transformation of rat fibroblastic cells.

1 reference

12 December 2020

Identification of pancreatic cancer stem cells

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12 December 2020

Hypoxia-inducible factors, stem cells, and cancer

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12 December 2020

Phenotypic characterization of human colorectal cancer stem cells

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12 December 2020

Significance of CD90+ cancer stem cells in human liver cancer

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12 December 2020

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer.

1 reference

12 December 2020

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family overexpression in human lung tumor

1 reference

12 December 2020

Stromal hyaluronan interaction with epithelial CD44 variants promotes prostate cancer invasiveness by augmenting expression and function of hepatocyte growth factor and androgen receptor

1 reference

12 December 2020

CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?

1 reference

12 December 2020

RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival.

1 reference

12 December 2020

CD44 proteolysis increases CREB phosphorylation and sustains proliferation of thyroid cancer cells

1 reference

12 December 2020

Identification of function for CD44 intracytoplasmic domain (CD44-ICD): modulation of matrix metalloproteinase 9 (MMP-9) transcription via novel promoter response element

1 reference

12 December 2020

Cancer stem cells: current status and evolving complexities

1 reference

12 December 2020

From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor-1 expression in cancers

1 reference

12 December 2020

Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression leading to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma

1 reference

12 December 2020

Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling

1 reference

12 December 2020

Cancer stem cells: the challenges ahead

1 reference

12 December 2020

Targeting unique metabolic properties of breast tumor initiating cells

1 reference

12 December 2020

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

1 reference

12 December 2020

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment.

1 reference

12 December 2020

Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth

1 reference

12 December 2020

Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors

1 reference

12 December 2020

Clinical significance of CD44s, CD44v3 and CD44v6 in breast cancer.

1 reference

12 December 2020

Cleaved CD44 intracellular domain supports activation of stemness factors and promotes tumorigenesis of breast cancer

1 reference

12 December 2020

CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells

1 reference

12 December 2020

Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor

1 reference

12 December 2020

Key Roles of Hyaluronan and Its CD44 Receptor in the Stemness and Survival of Cancer Stem Cells

1 reference

12 December 2020

Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation

1 reference

12 December 2020

The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma

1 reference

12 December 2020

Variant isoforms of CD44 expression in upper tract urothelial cancer as a predictive marker for recurrence and mortality.

1 reference

12 December 2020

HIF-1α activates hypoxia-induced PFKFB4 expression in human bladder cancer cells

1 reference

12 December 2020

Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes

1 reference

12 December 2020

TLR4 Promotes Breast Cancer Metastasis via Akt/GSK3β/β-Catenin Pathway upon LPS Stimulation

1 reference

12 December 2020

Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells

1 reference

12 December 2020

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.

1 reference

12 December 2020