Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth (Q34334355)

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English	Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth	scientific article

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scholarly article

1 reference

Europe PubMed Central

1 August 2017

Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth (English)

1 reference

Europe PubMed Central

1 August 2017

0 references

author name string

Jason Chesney

1

1 reference

Europe PubMed Central

1 August 2017

Jennifer Clark

2

1 reference

Europe PubMed Central

1 August 2017

Alden C Klarer

3

1 reference

Europe PubMed Central

1 August 2017

Yoannis Imbert-Fernandez

4

1 reference

Europe PubMed Central

1 August 2017

Andrew N Lane

5

1 reference

Europe PubMed Central

1 August 2017

Sucheta Telang

6

1 reference

Europe PubMed Central

1 August 2017

language of work or name

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publication date

1 August 2014

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

5

1 reference

Europe PubMed Central

1 August 2017

16

1 reference

Europe PubMed Central

1 August 2017

6670-6686

1 reference

Europe PubMed Central

1 August 2017

Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196155

6 July 2018

Increased concentrations of fructose 2,6-bisphosphate contribute to the Warburg effect in phosphatase and tensin homolog (PTEN)-deficient cells.

1 reference

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Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer

1 reference

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6 July 2018

Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival.

1 reference

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6 July 2018

Systemic elevation of PTEN induces a tumor-suppressive metabolic state

1 reference

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6 July 2018

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer.

1 reference

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6 July 2018

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.

1 reference

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The oncoprotein H-RasV12 increases mitochondrial metabolism

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Isotopomer-based metabolomic analysis by NMR and mass spectrometry

1 reference

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Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers

1 reference

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6 July 2018

Ras transformation requires metabolic control by 6-phosphofructo-2-kinase

1 reference

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6 July 2018

Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196155

6 July 2018

Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196155

6 July 2018

Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196155

6 July 2018

Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196155

6 July 2018

Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect

1 reference

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6 July 2018

The human ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFB3): promoter characterization and genomic structure

1 reference

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6 July 2018

PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate.

1 reference

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Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene

1 reference

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6 July 2018

An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect

1 reference

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6 July 2018

Characterization of a human placental fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196155

6 July 2018

Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.

1 reference

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6 July 2018

Control of the fructose-6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase

1 reference

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Use of nude mouse xenografts as preclinical drug screens: in vivo activity of established chemotherapeutic agents against melanoma and ovarian carcinoma xenografts.

1 reference

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Differences in phosphate metabolite levels in drug-sensitive and -resistant human breast cancer cell lines determined by 31P magnetic resonance spectroscopy.

1 reference

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6 July 2018

Tissue distribution, immunoreactivity, and physical properties of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

1 reference

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Molecular cloning of the DNA and expression and characterization of rat testes fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase

1 reference

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Marked, homogeneous, and early [18F]fluorodeoxyglucose-positron emission tomography responses to vemurafenib in BRAF-mutant advanced melanoma.

1 reference

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27 October 2018

RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196155

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Human placental fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase: its isozymic form, expression and characterization.

1 reference

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27 October 2018

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family overexpression in human lung tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/25115398

12 December 2020

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A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/25115398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.2213

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24 November 2022

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Europe PubMed Central

1 August 2017

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Europe PubMed Central

1 August 2017

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