CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? (Q37851351)

24 August 2017

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title

CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? (English)

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24 August 2017

Margot Zöller

1

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PubMed ID

21390059

24 August 2017

language of work or name

English

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publication date

10 March 2011

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24 August 2017

Nature Reviews Cancer

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24 August 2017

11

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24 August 2017

254-267

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24 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrc3023

24 August 2017

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cites work

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A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

31 March 2020

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Involvement of CD44, a molecule with a thousand faces, in cancer dissemination.

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A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

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A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins

31 March 2020

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CD44 is the principal cell surface receptor for hyaluronate

31 March 2020

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Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons

31 March 2020

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Isolation and DNA sequence of a cDNA clone encoding a lymphocyte adhesion receptor for high endothelium

31 March 2020

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Identification of mRNA that encodes an alternative form of H-CAM(CD44) in lymphoid and nonlymphoid tissues

31 March 2020

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Identification of hyaluronic acid binding sites in the extracellular domain of CD44

31 March 2020

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CD44 participates in the adhesion of human colorectal carcinoma cells to laminin and type IV collagen

31 March 2020

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Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin

31 March 2020

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Cancer cells in transit: the vascular interactions of tumor cells

31 March 2020

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A novel ligand for CD44 is sulfated proteoglycan

31 March 2020

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Characterization of the heparan sulfate and chondroitin sulfate assembly sites in CD44

31 March 2020

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Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

31 March 2020

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Alterations of pre-mRNA splicing in cancer.

31 March 2020

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The cytoplasmic tail of CD44 is required for basolateral localization in epithelial MDCK cells but does not mediate association with the detergent-insoluble cytoskeleton of fibroblasts

31 March 2020

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CD44 isoforms during differentiation and development

31 March 2020

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CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor

31 March 2020

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Adhesion proteins meet receptors: a common theme?

31 March 2020

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A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis.

31 March 2020

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Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton

31 March 2020

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Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function

31 March 2020

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Organizing the cell cortex: the role of ERM proteins

31 March 2020

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Structural Basis for CD44 Recognition by ERM Proteins

31 March 2020

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Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival

31 March 2020

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

31 March 2020

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

31 March 2020

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

31 March 2020

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Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

31 March 2020

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Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

31 March 2020

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The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

31 March 2020

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The biology of cancer stem cells

31 March 2020

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Phenotypes of stem cells from diverse origin

31 March 2020

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

31 March 2020

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Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

31 March 2020

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Modulation of microRNA processing by p53

31 March 2020

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Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs.

31 March 2020

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Novel roles for Notch, Wnt and Hedgehog in hematopoesis derived from human pluripotent stem cells

31 March 2020

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APC and its modifiers in colon cancer.

31 March 2020

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Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway

31 March 2020

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Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemothera

31 March 2020

1 reference

Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression

31 March 2020

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The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

31 March 2020

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Alternative splicing in cancer: noise, functional, or systematic?

31 March 2020

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The connection between splicing and cancer.

31 March 2020

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Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

31 March 2020

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Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer

31 March 2020

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SLUG/SNAI2 and tumor necrosis factor generate breast cells with CD44+/CD24- phenotype.

31 March 2020

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31 March 2020

The stem cell movement.

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31 March 2020

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Hyaluronan: from extracellular glue to pericellular cue.

31 March 2020

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How do stem cells find their way home?

31 March 2020

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Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures

31 March 2020

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Activation of beta1 integrins on CML progenitors reveals cooperation between beta1 integrins and CD44 in the regulation of adhesion and proliferation

31 March 2020

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CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow.

31 March 2020

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Targeting of CD44 eradicates human acute myeloid leukemic stem cells

31 March 2020

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Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells

31 March 2020

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Thymus repopulation after allogeneic reconstitution in hematological malignancies

31 March 2020

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Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells

31 March 2020

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Hyaluronan facilitates invasion of colon carcinoma cells in vitro via interaction with CD44.

31 March 2020

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The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion

31 March 2020

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Hyaluronan binding properties of a CD44 chimera containing the link module of TSG-6.

31 March 2020

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PKC-induced stiffening of hyaluronan/CD44 linkage; local force measurements on glioma cells

31 March 2020

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CD44H regulates tumor cell migration on hyaluronate-coated substrate

31 March 2020

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Hyaluronic acid (HA) binding to CD44 activates Rac1 and induces lamellipodia outgrowth

31 March 2020

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Regulatory and signaling properties of the Vav family

31 March 2020

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31 March 2020

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Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression

31 March 2020

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In vivo CD44-CD49d complex formation in autoimmune disease has consequences on T cell activation and apoptosis resistance

31 March 2020

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Mechanism and biological significance of CD44 cleavage

31 March 2020

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Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation

31 March 2020

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Constitutive and induced CD44 shedding by ADAM-like proteases and membrane-type 1 matrix metalloproteinase.

31 March 2020

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Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells

31 March 2020

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Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors

31 March 2020

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CD44v6 dependence of premetastatic niche preparation by exosomes

31 March 2020

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Characterization of the expression of variant and standard CD44 in prostate cancer cells: identification of the possible molecular mechanism of CD44/MMP9 complex formation on the cell surface

31 March 2020

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Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion

31 March 2020

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Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand

31 March 2020

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Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction

31 March 2020

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Gamma-secretase-dependent proteolysis of CD44 promotes neoplastic transformation of rat fibroblastic cells.

31 March 2020

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One hundred years of positional information

31 March 2020

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Normal stem cells and cancer stem cells: the niche matters

31 March 2020

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Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

31 March 2020

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Reprogramming metastatic tumour cells with embryonic microenvironments

31 March 2020

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Stem cells and niches: mechanisms that promote stem cell maintenance throughout life

31 March 2020

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Niche retreats for stem cells

31 March 2020

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Association between cancer and "acid mucopolysaccharides": an old concept comes of age, finally

31 March 2020

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The magic glue hyaluronan and its eraser hyaluronidase: a biological overview

31 March 2020

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Regulation of stemness and stem cell niche of mesenchymal stem cells: implications in tumorigenesis and metastasis

31 March 2020

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Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

31 March 2020

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Altered hyaluronan biosynthesis in cancer progression

31 March 2020

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CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance.

31 March 2020

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Hyaluronan and hyaluronan synthases: potential therapeutic targets in cancer.

31 March 2020

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Down-regulation of hepatoma-derived growth factor inhibits anchorage-independent growth and invasion of non-small cell lung cancer cells

31 March 2020

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CLU "in and out": looking for a link.

31 March 2020

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Complement activation on platelets: implications for vascular inflammation and thrombosis

31 March 2020

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Transmembrane signaling proteoglycans

31 March 2020

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Osteopontin: regulation in tumor metastasis

31 March 2020

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bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells

31 March 2020

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Heparan Sulfate-modified CD44 Promotes Hepatocyte Growth Factor/Scatter Factor-induced Signal Transduction through the Receptor Tyrosine Kinase c-Met

31 March 2020

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A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth

31 March 2020

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CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling

31 March 2020

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Molecular mechanisms of metastasis

31 March 2020

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Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

31 March 2020

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

31 March 2020

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Metastasis and stem cell pathways

31 March 2020

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CD44: from adhesion molecules to signalling regulators

31 March 2020

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CD44 in cancer progression: adhesion, migration and growth regulation

31 March 2020

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The epithelial-mesenchymal transition generates cells with properties of stem cells

31 March 2020

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Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer

31 March 2020

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Beta-catenin--a linchpin in colorectal carcinogenesis?

31 March 2020

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Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells

31 March 2020

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A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells

31 March 2020

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Nuclear beta-catenin and CD44 upregulation characterize invasive cell populations in non-aggressive MCF-7 breast cancer cells

31 March 2020

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Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.

31 March 2020

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Fibroblast migration is mediated by CD44-dependent TGF beta activation

31 March 2020

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CD44 signaling through focal adhesion kinase and its anti-apoptotic effect

31 March 2020

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Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function

31 March 2020

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CD44 and EpCAM: cancer-initiating cell markers

31 March 2020

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Hyaluronan and the interaction between CD44 and epidermal growth factor receptor in oncogenic signaling and chemotherapy resistance in head and neck cancer

31 March 2020

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CD44 enhances neuregulin signaling by Schwann cells

31 March 2020

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Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells.

31 March 2020

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Hyaluronan, CD44, and cyclooxygenase-2 in colon cancer

31 March 2020

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Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin

31 March 2020

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Haploinsufficiency of c-Met in cd44-/- mice identifies a collaboration of CD44 and c-Met in vivo

31 March 2020

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Tyrosine kinases as targets for cancer therapy

31 March 2020

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Hyaluronan constitutively regulates activation of multiple receptor tyrosine kinases in epithelial and carcinoma cells

31 March 2020

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Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor

31 March 2020

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Transforming growth factor-beta facilitates breast carcinoma metastasis by promoting tumor cell survival

31 March 2020

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A mechanism for SRC kinase-dependent signaling by noncatalytic receptors

31 March 2020

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Src family kinases: regulation of their activities, levels and identification of new pathways

31 March 2020

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The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer

31 March 2020

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Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2.

31 March 2020

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Tumour stem cells and drug resistance

31 March 2020

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The impact of extracellular matrix on the chemoresistance of solid tumors--experimental and clinical results of hyaluronidase as additive to cytostatic chemotherapy.

31 March 2020

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Abrogating drug resistance in malignant peripheral nerve sheath tumors by disrupting hyaluronan-CD44 interactions with small hyaluronan oligosaccharides

31 March 2020

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Hyaluronan substratum induces multidrug resistance in human mesenchymal stem cells via CD44 signaling.

31 March 2020

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CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastoma

31 March 2020

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Epithelial-mesenchymal transitions in development and disease

31 March 2020

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Examining the metastatic niche: targeting the microenvironment

31 March 2020

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The tumorigenicity of diploid and aneuploid human pluripotent stem cells

31 March 2020

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Identification and targeting of cancer stem cells

31 March 2020

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Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression

31 March 2020

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CD44 variant exons in leukemia and lymphoma

31 March 2020

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Anti-idiotype x anti-CD44 bispecific antibodies inhibit invasion of lymphoid organs by B cell lymphoma

31 March 2020

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Significance of CD90+ cancer stem cells in human liver cancer

31 March 2020

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Prevention of tumor metastasis formation by anti-variant CD44.

31 March 2020

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Safety and pharmacokinetics of bivatuzumab mertansine in patients with CD44v6-positive metastatic breast cancer: final results of a phase I study

31 March 2020

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A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus

31 March 2020

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Development of a bispecific F(ab')2 conjugate against the complement receptor CR3 of macrophages and a variant CD44 antigen of rat pancreatic adenocarcinoma for redirecting macrophage-mediated tumor cytotoxicity

31 March 2020

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Identification of an active site on the laminin alpha5 chain globular domain that binds to CD44 and inhibits malignancy.

31 March 2020

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Laminin alpha5 chain metastasis- and angiogenesis-inhibiting peptide blocks fibroblast growth factor 2 activity by binding to the heparan sulfate chains of CD44.

31 March 2020

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Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan Oligosaccharides

31 March 2020

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Versican induces a pro-metastatic ovarian cancer cell behavior which can be inhibited by small hyaluronan oligosaccharides

31 March 2020

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Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44.

31 March 2020

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Hyaluronic acid-paclitaxel: effects of intraperitoneal administration against CD44(+) human ovarian cancer xenografts.

31 March 2020

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Paclitaxel-clusters coated with hyaluronan as selective tumor-targeted nanovectors.

31 March 2020

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The expression of activated Y-box binding protein-1 serine 102 mediates trastuzumab resistance in breast cancer cells by increasing CD44+ cells

31 March 2020

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

31 March 2020

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A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer

31 March 2020

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TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma

31 March 2020

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Tumor cell-associated hyaluronan as an unfavorable prognostic factor in colorectal cancer

31 March 2020

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12 December 2020

A CD44 survival pathway triggers chemoresistance via lyn kinase and phosphoinositide 3-kinase/Akt in colon carcinoma cells.

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12 December 2020

CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis

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12 December 2020

CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells

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12 December 2020

Ligation of the CD44 adhesion molecule inhibits drug-induced apoptosis in human myeloid leukemia cells.

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12 December 2020

Phorbol myristate acetate stimulates the dimerization of CD44 involving a cysteine in the transmembrane domain

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12 December 2020

Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells.

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12 December 2020

New advances on critical implications of tumor- and metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence

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12 December 2020

CD44v6, a target for novel antibody treatment approaches, is frequently expressed in multiple myeloma and associated with deletion of chromosome arm 13q

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12 December 2020

Heterogeneous populations of bone marrow stem cells--are we spotting on the same cells from the different angles?

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12 December 2020

Hyaluronic acid induces osteopontin via the phosphatidylinositol 3-kinase/Akt pathway to enhance the motility of human glioma cells.

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12 December 2020

Absence of the CD44 gene prevents sarcoma metastasis.

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12 December 2020

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

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12 December 2020

Cancer stem cells--normal stem cells "Jedi" that went over to the "dark side".

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12 December 2020

The emerging role of CD44 in regulating skeletal micrometastasis.

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12 December 2020

The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse, human, and rat.

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12 December 2020

CD44 and its interaction with extracellular matrix.

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12 December 2020

CD44 and hematologic malignancies.

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12 December 2020

A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors

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12 December 2020

Adult stem and transit-amplifying cell location

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12 December 2020

Engagement of variant CD44 confers resistance to anti-integrin antibody-mediated apoptosis in a colon carcinoma cell line

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12 December 2020

Identifiers

DOI

10.1038/NRC3023

1 reference

24 August 2017

1 reference

PubMed ID

21390059