Hypoxia--a key regulatory factor in tumour growth (Q29547318)

Europe PubMed Central

title

Hypoxia--a key regulatory factor in tumour growth (English)

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23 April 2017

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Harris AL

1

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23 April 2017

language of work or name

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23 April 2017

publication date

January 2002

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23 April 2017

published in

Nature Reviews Cancer

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23 April 2017

volume

2

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23 April 2017

page(s)

38-47

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23 April 2017

issue

1

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The histological structure of some human lung cancers and the possible implications for radiotherapy

23 April 2017

cites work

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Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms

31 March 2020

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Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

31 March 2020

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Oncogenic alterations of metabolism

31 March 2020

1 reference

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

31 March 2020

1 reference

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

31 March 2020

1 reference

A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.

31 March 2020

1 reference

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

31 March 2020

1 reference

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

31 March 2020

1 reference

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

31 March 2020

1 reference

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

31 March 2020

1 reference

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

31 March 2020

1 reference

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

31 March 2020

1 reference

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

31 March 2020

1 reference

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

31 March 2020

1 reference

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

31 March 2020

1 reference

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

31 March 2020

1 reference

Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway.

31 March 2020

1 reference

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

31 March 2020

1 reference

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

31 March 2020

1 reference

A conserved family of prolyl-4-hydroxylases that modify HIF

31 March 2020

1 reference

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

31 March 2020

1 reference

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

31 March 2020

1 reference

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

31 March 2020

1 reference

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

31 March 2020

1 reference

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

31 March 2020

1 reference

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

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Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

31 March 2020

1 reference

Transcriptional response to hypoxia in human tumors

31 March 2020

1 reference

Signaling angiogenesis via p42/p44 MAP kinase and hypoxia

31 March 2020

1 reference

EPAS1 trans-activation during hypoxia requires p42/p44 MAPK

31 March 2020

1 reference

The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy

31 March 2020

1 reference

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

31 March 2020

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Heterogeneous vascular dependence of tumor cell populations

31 March 2020

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Suppression of tumor growth through disruption of hypoxia-inducible transcription

31 March 2020

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Thrombospondins and tumor angiogenesis

31 March 2020

1 reference

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

31 March 2020

1 reference

Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia

31 March 2020

1 reference

Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells.

31 March 2020

1 reference

A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs

31 March 2020

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Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

31 March 2020

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Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

31 March 2020

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BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore

31 March 2020

1 reference

Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia

31 March 2020

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

31 March 2020

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Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

31 March 2020

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Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

31 March 2020

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Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

31 March 2020

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Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms

31 March 2020

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Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes

31 March 2020

1 reference

Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma

31 March 2020

1 reference

The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase

31 March 2020

1 reference

Hypoxia inhibits G1/S transition through regulation of p27 expression

31 March 2020

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p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest

31 March 2020

1 reference

Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia

31 March 2020

1 reference

Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells

31 March 2020

1 reference

Hypoxia-associated induction of early growth response-1 gene expression

31 March 2020

1 reference

A pathway leading to hypoxia-induced vascular fibrin deposition

31 March 2020

1 reference

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

31 March 2020

1 reference

The impact of hemoglobin levels on treatment outcomes in patients with cancer

31 March 2020

1 reference

Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results of a randomized, double-blind, placebo-controlled trial.

31 March 2020

1 reference

ARCON: accelerated radiotherapy with carbogen and nicotinamide in head and neck squamous cell carcinomas. The experience of the Co-operative group of radiotherapy of the european organization for research and treatment of cancer (EORTC).

31 March 2020

1 reference

Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia

31 March 2020

1 reference

Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors.

31 March 2020

1 reference

Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy

31 March 2020

1 reference

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

31 March 2020

1 reference

Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing

31 March 2020

1 reference

Targeting gene expression to hypoxic tumor cells

31 March 2020

1 reference

Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment

31 March 2020

1 reference

The macrophage - a novel system to deliver gene therapy to pathological hypoxia

31 March 2020

1 reference

The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression

31 March 2020

1 reference

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

31 March 2020

1 reference

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

31 March 2020

1 reference

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

31 March 2020

1 reference

Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP.

31 March 2020

1 reference

The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia

31 March 2020

1 reference

The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

31 March 2020

1 reference

aHIF: a natural antisense transcript overexpressed in human renal cancer and during hypoxia

31 March 2020

1 reference

Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR

31 March 2020

1 reference

Sequencing of the human vascular endothelial growth factor (VEGF) 3' untranslated region (UTR): conservation of five hypoxia-inducible RNA-protein binding sites.

31 March 2020

1 reference

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

31 March 2020

1 reference

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

31 March 2020

1 reference

Rac1 activity is required for the activation of hypoxia-inducible factor 1.

31 March 2020

1 reference

Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension

31 March 2020

1 reference

Human hepatitis B virus X protein is a possible mediator of hypoxia-induced angiogenesis in hepatocarcinogenesis

31 March 2020

1 reference

Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

31 March 2020

1 reference

Regulation of proliferation-survival decisions during tumor cell hypoxia

31 March 2020

1 reference

Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

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23 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

236783

1028740665

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236783

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11902584

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23 April 2017

Consolidated OpenCitations Corpus – April 2017