Lysosome: The Metabolic Signaling Hub (Q57286714)

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27 April 2020

title

Lysosome: The metabolic signaling hub (English)

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1

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Liron Bar-Peled

series ordinal

2

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27 April 2020

author name string

Dudley W Lamming

series ordinal

1

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Liron Bar-Peled

series ordinal

2

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language of work or name

English

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publication date

14 November 2018

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volume

20

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issue

1

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page(s)

27-38

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Peptide sequences that target cytosolic proteins for lysosomal proteolysis

27 April 2020

cites work

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12 December 2020

Characterization of the isolation membranes and the limiting membranes of autophagosomes in rat hepatocytes by lectin cytochemistry

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12 December 2020

A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

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12 December 2020

The discovery of lysosomes

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12 December 2020

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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12 December 2020

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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12 December 2020

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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12 December 2020

Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae

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12 December 2020

A receptor for the selective uptake and degradation of proteins by lysosomes

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12 December 2020

An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation

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12 December 2020

Regulation of eIF-4E BP1 phosphorylation by mTOR.

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12 December 2020

RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway

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12 December 2020

Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members

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12 December 2020

TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals

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12 December 2020

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B

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12 December 2020

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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12 December 2020

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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12 December 2020

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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12 December 2020

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

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12 December 2020

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

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12 December 2020

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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12 December 2020

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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12 December 2020

Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals

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12 December 2020

Isolation and biochemical properties of droplets from the cells of rat kidney

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12 December 2020

Localization of acid phosphatase activity in hepatic lysosomes by means of electron microscopy

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12 December 2020

TSC2 mediates cellular energy response to control cell growth and survival

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12 December 2020

Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress

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12 December 2020

Linking albinism and immunity: the secrets of secretory lysosomes

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12 December 2020

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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12 December 2020

Role for Rab7 in maturation of late autophagic vacuoles

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12 December 2020

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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12 December 2020

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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12 December 2020

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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12 December 2020

The TOR and EGO protein complexes orchestrate microautophagy in yeast

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12 December 2020

The lysosome turns fifty

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12 December 2020

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

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12 December 2020

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

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12 December 2020

A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.

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12 December 2020

Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1.

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12 December 2020

IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

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12 December 2020

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

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12 December 2020

Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway

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12 December 2020

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

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12 December 2020

Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.

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12 December 2020

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

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12 December 2020

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

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12 December 2020

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

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12 December 2020

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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12 December 2020

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

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12 December 2020

Regulation of TORC1 by Rag GTPases in nutrient response

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12 December 2020

The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane

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12 December 2020

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

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12 December 2020

A gene network regulating lysosomal biogenesis and function

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12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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12 December 2020

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

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12 December 2020

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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12 December 2020

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

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12 December 2020

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

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12 December 2020

Protein homeostasis and aging: The importance of exquisite quality control

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12 December 2020

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

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12 December 2020

Mitochondria supply membranes for autophagosome biogenesis during starvation

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12 December 2020

Termination of autophagy and reformation of lysosomes regulated by mTOR

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12 December 2020

Plasma membrane contributes to the formation of pre-autophagosomal structures

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12 December 2020

Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals

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12 December 2020

The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7.

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12 December 2020

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

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12 December 2020

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

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12 December 2020

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

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12 December 2020

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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12 December 2020

Activation of mTORC2 by association with the ribosome

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12 December 2020

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

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12 December 2020

LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis

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12 December 2020

TFEB links autophagy to lysosomal biogenesis

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12 December 2020

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

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12 December 2020

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.

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12 December 2020

The cellular pathology of lysosomal diseases

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12 December 2020

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

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12 December 2020

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

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12 December 2020

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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12 December 2020

The metabolic footprint of aging in mice

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12 December 2020

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

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12 December 2020

Glutaminolysis activates Rag-mTORC1 signaling.

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12 December 2020

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

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12 December 2020

Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation

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12 December 2020

A complex immunodeficiency is based on U1 snRNP-mediated poly(A) site suppression.

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12 December 2020

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

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12 December 2020

Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice

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12 December 2020

Endocytosis and autophagy: Shared machinery for degradation.

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12 December 2020

The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes

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12 December 2020

The lipid kinase PI4KIIIβ preserves lysosomal identity

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12 December 2020

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

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12 December 2020

ZKSCAN3 is a master transcriptional repressor of autophagy

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12 December 2020

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

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12 December 2020

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.

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12 December 2020

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

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12 December 2020

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

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12 December 2020

Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

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12 December 2020

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin

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12 December 2020

Overexpression of Atg5 in mice activates autophagy and extends lifespan

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12 December 2020

A Central role for mTOR in lipid homeostasis

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12 December 2020

SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation

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12 December 2020

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression

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12 December 2020

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

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12 December 2020

Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases

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12 December 2020

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

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12 December 2020

Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-кB cascade in astrocytic oxygen-glucose deprivation

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12 December 2020

Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.

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12 December 2020

Chaperone-mediated autophagy: roles in disease and aging

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12 December 2020

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

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12 December 2020

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.

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12 December 2020

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17

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12 December 2020

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

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12 December 2020

RagA, but not RagB, is essential for embryonic development and adult mice

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12 December 2020

Autophagy and human disease: emerging themes

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12 December 2020

Phosphorylation of Akt at the C-terminal tail triggers Akt activation

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12 December 2020

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

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12 December 2020

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

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12 December 2020

Response and acquired resistance to everolimus in anaplastic thyroid cancer

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12 December 2020

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12 December 2020

Transcriptional regulation of autophagy by an FXR-CREB axis

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12 December 2020

Nutrient-sensing nuclear receptors coordinate autophagy

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12 December 2020

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

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12 December 2020

PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins

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12 December 2020

mTOR inhibition improves immune function in the elderly

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12 December 2020

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

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12 December 2020

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

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12 December 2020

The role for autophagy in cancer

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12 December 2020

Diminished mTOR signaling: a common mode of action for endocrine longevity factors.

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12 December 2020

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

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12 December 2020

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.

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12 December 2020

Nutrient-sensing mechanisms across evolution

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12 December 2020

mTORC2 regulates cardiac response to stress by inhibiting MST1.

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12 December 2020

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12 December 2020

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

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12 December 2020

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

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12 December 2020

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.

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12 December 2020

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

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12 December 2020

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

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12 December 2020

Sestrin2 is a leucine sensor for the mTORC1 pathway

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12 December 2020

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

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12 December 2020

Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy.

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12 December 2020

Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2.

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12 December 2020

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

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12 December 2020

Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice

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12 December 2020

Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse

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12 December 2020

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

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12 December 2020

Determinants of rodent longevity in the chaperone-protein degradation network

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12 December 2020

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

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12 December 2020

Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia

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12 December 2020

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice

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12 December 2020

Nϵ-lysine acetylation in the lumen of the endoplasmic reticulum: A way to regulate autophagy and maintain protein homeostasis in the secretory pathway

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12 December 2020

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.

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12 December 2020

Kinesin 1 Drives Autolysosome Tubulation

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12 December 2020

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12 December 2020

FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1.

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12 December 2020

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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12 December 2020

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

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12 December 2020

Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice

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12 December 2020

The Lysosome as a Regulatory Hub.

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12 December 2020

Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles

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12 December 2020

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.

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12 December 2020

Cutting back on the essentials: Can manipulating intake of specific amino acids modulate health and lifespan?

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12 December 2020

mTORC2 Puts Its Shoulder to Krebs' Wheel.

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12 December 2020

The apo-structure of the leucine sensor Sestrin2 is still elusive

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12 December 2020

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

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12 December 2020

SZT2 dictates GATOR control of mTORC1 signalling.

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12 December 2020

Autophagy, Metabolism, and Cancer

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12 December 2020

Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.

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12 December 2020

Recent progress in autophagic lysosome reformation

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12 December 2020

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.

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12 December 2020

Targeting autophagy in cancer

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12 December 2020

Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice.

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12 December 2020

RHEB1 insufficiency in aged male mice is associated with stress-induced seizures.

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12 December 2020

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.

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12 December 2020

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

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12 December 2020

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes.

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12 December 2020

Twenty-five years of mTOR: Uncovering the link from nutrients to growth.

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12 December 2020

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.

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12 December 2020

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.

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12 December 2020

Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.

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12 December 2020

Structural basis for the assembly of the Ragulator-Rag GTPase complex

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12 December 2020

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy

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12 December 2020

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.

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12 December 2020

Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response.

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12 December 2020

Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology

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12 December 2020

Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms.

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12 December 2020

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance.

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12 December 2020

Targeting the PI3K pathway in cancer: are we making headway?

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12 December 2020

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.

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12 December 2020

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

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12 December 2020

Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation

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12 December 2020

GATOR1-dependent recruitment of FLCN-FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids.

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12 December 2020

mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a

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12 December 2020

Association Between Autophagy and Neurodegenerative Diseases.

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12 December 2020

Regulation of metabolic health by essential dietary amino acids

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12 December 2020

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

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12 December 2020

Identifiers

DOI

10.1111/TRA.12617

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27 April 2020

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27 April 2020

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