mTORC2 regulates cardiac response to stress by inhibiting MST1. (Q40182849)

18 September 2017

mTORC2 regulates cardiac response to stress by inhibiting MST1. (English)

1 reference

18 September 2017

9

1 reference

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8 June 2020

Sebastiano Sciarretta

1

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8 June 2020

Giacomo Frati

10

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8 June 2020

Junichi Sadoshima

12

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8 June 2020

7

Tong Liu

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8 June 2020

author name string

Peiyong Zhai

2

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8 June 2020

Yasuhiro Maejima

3

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8 June 2020

Dominic P Del Re

4

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8 June 2020

Narayani Nagarajan

5

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8 June 2020

Derek Yee

6

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8 June 2020

Mark A Magnuson

8

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8 June 2020

Hong Li

11

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8 June 2020

publication date

2 April 2015

1 reference

18 September 2017

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8 June 2020

volume

11

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8 June 2020

page(s)

125-136

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8 June 2020

issue

1

1 reference

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Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

8 June 2020

cites work

1 reference

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The mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy

22 September 2017

1 reference

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Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL

22 September 2017

1 reference

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Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling

22 September 2017

1 reference

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Mammalian target of rapamycin signaling in cardiac physiology and disease.

22 September 2017

1 reference

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Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.

22 September 2017

1 reference

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Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage

22 September 2017

1 reference

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A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.

22 September 2017

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The Hippo pathway: regulators and regulations

22 September 2017

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Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period

22 September 2017

1 reference

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Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth

22 September 2017

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Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury

22 September 2017

1 reference

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YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

22 September 2017

1 reference

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Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling.

22 September 2017

1 reference

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Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.

22 September 2017

1 reference

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mTOR signaling in growth control and disease

22 September 2017

1 reference

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

22 September 2017

1 reference

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Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

22 September 2017

1 reference

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Endoplasmic reticulum is a main localization site of mTORC2.

22 September 2017

1 reference

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Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

22 September 2017

1 reference

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MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling

22 September 2017

1 reference

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IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

22 September 2017

1 reference

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The hippo signaling pathway in development and cancer

22 September 2017

1 reference

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MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

22 September 2017

1 reference

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Rictor is a novel target of p70 S6 kinase-1.

22 September 2017

1 reference

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Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

22 September 2017

1 reference

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Large-scale proteomics analysis of the human kinome

22 September 2017

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Monitoring mammalian target of rapamycin (mTOR) activity

22 September 2017

1 reference

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

22 September 2017

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

22 September 2017

1 reference

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

22 September 2017

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

22 September 2017

1 reference

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Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway

22 September 2017

1 reference

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

22 September 2017

1 reference

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

22 September 2017

1 reference

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Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417361

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417361

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417361

TOR signaling in growth and metabolism

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417361

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417361

Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417361

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

22 September 2017

1 reference

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417361

Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417361

PKC-alpha regulates cardiac contractility and propensity toward heart failure

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417361

Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417361

Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice

22 September 2017

1 reference

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Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes

15 June 2018

1 reference

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Yap1, transcription regulator in the Hippo signaling pathway, is required for Xenopus limb bud regeneration.

15 June 2018

1 reference

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Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417361

Akt1 is required for physiological cardiac growth

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25843706

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2015.03.010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25843706%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25843706%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25843706%20AND%20SRC:MED&resulttype=core&format=json