PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. (Q36244792)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26293922%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex (English)

1 reference

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22 February 2020

9

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22 February 2020

Yuet Ming Rebecca Chin

3

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22 February 2020

author name string

Pengda Liu

1

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22 February 2020

Wenjian Gan

2

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22 February 2020

Kohei Ogura

4

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22 February 2020

Jianping Guo

5

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22 February 2020

Jinfang Zhang

6

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22 February 2020

Bin Wang

7

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22 February 2020

John Blenis

8

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22 February 2020

Alex Toker

10

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22 February 2020

Bing Su

11

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22 February 2020

Wenyi Wei

12

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22 February 2020

language of work or name

1 reference

20 August 2015

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22 February 2020

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22 February 2020

volume

5

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22 February 2020

page(s)

1194-1209

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22 February 2020

issue

11

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Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

22 February 2020

cites work

1 reference

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Metabolism. Differential regulation of mTORC1 by leucine and glutamine

1 October 2017

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Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

1 October 2017

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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

1 October 2017

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Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown

1 October 2017

1 reference

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Regulation of mTORC1 by amino acids

1 October 2017

1 reference

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Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

1 October 2017

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Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity

1 October 2017

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Where is mTOR and what is it doing there?

1 October 2017

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mTOR kinase structure, mechanism and regulation

1 October 2017

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In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.

1 October 2017

1 reference

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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

1 October 2017

1 reference

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Structures of the pleckstrin homology domain ofSaccharomyces cerevisiaeAvo1 and its human orthologue Sin1, an essential subunit of TOR complex 2

1 October 2017

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mTOR signaling in growth control and disease

1 October 2017

1 reference

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Regulating the regulator: post-translational modification of RAS

1 October 2017

1 reference

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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

1 October 2017

1 reference

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Proteomic analysis of lipid raft-enriched membranes isolated from internal organelles

1 October 2017

1 reference

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mTORC2 targets AGC kinases through Sin1-dependent recruitment

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631654

Activation of mTORC2 by association with the ribosome

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631654

Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631654

mTOR: from growth signal integration to cancer, diabetes and ageing

1 October 2017

1 reference

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mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

1 October 2017

1 reference

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Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction

1 October 2017

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Oncogenic mutations of PIK3CA in human cancers

1 October 2017

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Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

1 October 2017

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631654

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

1 October 2017

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Defining the role of mTOR in cancer

1 October 2017

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Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling

1 October 2017

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Pleckstrin homology (PH) domains and phosphoinositides

1 October 2017

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

1 October 2017

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

1 October 2017

1 reference

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

1 October 2017

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

1 October 2017

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Molecular organization of target of rapamycin complex 2.

1 October 2017

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Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation

1 October 2017

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

1 October 2017

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The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins

1 October 2017

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Dysregulation of the TSC-mTOR pathway in human disease

1 October 2017

1 reference

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 October 2017

1 reference

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 October 2017

1 reference

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Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae

1 October 2017

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 October 2017

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4631654

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 October 2017

1 reference

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Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

1 October 2017

1 reference

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Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

1 October 2017

1 reference

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Conserved sequence motifs and the structure of the mTOR kinase domain

22 September 2018

1 reference

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Structural biology: Security measures of a master regulator

22 September 2018

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Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.

22 September 2018

1 reference

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Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26293922

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/2159-8290.CD-15-0460

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26293922%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26293922%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26293922%20AND%20SRC:MED&resulttype=core&format=json