Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death (Q36347249)

13 August 2017

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death (English)

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13 August 2017

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K Moriwaki

1

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13 August 2017

J Bertin

2

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13 August 2017

P J Gough

3

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13 August 2017

G M Orlowski

4

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13 August 2017

F K M Chan

5

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13 August 2017

12 February 2015

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13 August 2017

Cell Death and Disease

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13 August 2017

6

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13 August 2017

e1636

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Creative Commons Attribution 4.0 International

13 August 2017

start time

1 February 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4669795/fullTextXML

inferred from PubMed Central ID database lookup

cites work

The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair

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RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage

30 September 2017

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Therapeutic exploitation of necroptosis for cancer therapy

30 September 2017

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IAP family of cell death and signaling regulators

30 September 2017

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A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

30 September 2017

1 reference

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RIP3 overexpression sensitizes human breast cancer cells to parthenolide in vitro via intracellular ROS accumulation

30 September 2017

1 reference

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MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

30 September 2017

1 reference

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Staying alive: cell death in antiviral immunity

30 September 2017

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Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

30 September 2017

1 reference

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BIM upregulation and ROS-dependent necroptosis mediate the antitumor effects of the HDACi Givinostat and Sorafenib in Hodgkin lymphoma cell line xenografts.

30 September 2017

1 reference

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TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells

30 September 2017

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Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

30 September 2017

1 reference

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Necrosis-dependent and independent signaling of the RIP kinases in inflammation

30 September 2017

1 reference

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Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

30 September 2017

1 reference

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

30 September 2017

1 reference

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Smac mimetic primes apoptosis-resistant acute myeloid leukaemia cells for cytarabine-induced cell death by triggering necroptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis

30 September 2017

1 reference

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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

30 September 2017

1 reference

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RIP3: a molecular switch for necrosis and inflammation

30 September 2017

1 reference

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Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

30 September 2017

1 reference

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Lysosomal cell death at a glance.

30 September 2017

1 reference

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Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma.

30 September 2017

1 reference

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RIP1 potentiates BPDE-induced transformation in human bronchial epithelial cells through catalase-mediated suppression of excessive reactive oxygen species

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

30 September 2017

1 reference

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Immunogenic cell death in cancer therapy

30 September 2017

1 reference

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The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

30 September 2017

1 reference

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CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set.

30 September 2017

1 reference

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A novel role for RIP1 kinase in mediating TNFα production

30 September 2017

1 reference

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Cancer stem cells: in the line of fire

30 September 2017

1 reference

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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer

30 September 2017

1 reference

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A decade of exploring the cancer epigenome - biological and translational implications

30 September 2017

1 reference

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RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Targeting hypoxia in cancer therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Hallmarks of Cancer: The Next Generation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Functional complementation between FADD and RIP1 in embryos and lymphocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Non-caspase proteases: triggers or amplifiers of apoptosis?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Chemotherapeutic approaches for targeting cell death pathways

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Microarray analysis of promoter methylation in lung cancers.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

RIP3 induces apoptosis independent of pronecrotic kinase activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

RIPK3 as a potential therapeutic target for Gaucher's disease.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4669795

Inhibition of the interferon-gamma/signal transducers and activators of transcription (STAT) pathway by hypermethylation at a STAT-binding site in the p21WAF1 promoter region

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25675296

12 December 2020

inferred from PubMed ID database lookup

Shikonin circumvents cancer drug resistance by induction of a necroptotic death

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25675296

12 December 2020

inferred from PubMed ID database lookup

Programmed necrosis in the cross talk of cell death and inflammation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25675296

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/CDDIS.2015.16

1 reference

13 August 2017

1 reference

13 August 2017

1 reference